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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
EcoR1 Capital LLC	[2025-06-30]	SOLE	10,688,978	10,688,978
BlackRock, Inc.	[2025-06-30]	SOLE	4,275,603	4,574,537
Tang Capital Management LLC	[2025-06-30]	OTR	0	3,826,692
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,638,108
Boxer Capital Management LLC	[2025-06-30]	SOLE	0	825,000
Millennium Management LLC	[2025-06-30]	SOLE	477,189	819,689
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	732,639	766,441
Geode Capital Management LLC	[2025-06-30]	DFND	703,467	703,467
OrbiMed Advisors LLC	[2025-06-30]	DFND	327,600	700,000
Marshall Wace LLP	[2025-06-30]	OTR	0	611,649
Renaissance Technologies LLC	[2025-06-30]	SOLE	602,100	602,100
JPMorgan Chase & Co	[2025-06-30]	DFND	518,629	601,363
Nantahala Capital Management LLC	[2025-06-30]	SOLE	596,666	596,666
State Street Corp	[2025-06-30]	DFND	559,355	594,555
DLD Asset Management LP	[2025-06-30]	SOLE	576,655	576,655
Susquehanna International Group LLP	[2025-06-30]	OTR	144,080	570,580
Newtyn Management LLC	[2025-06-30]	SOLE	567,416	567,416
LMR Partners LLP	[2025-06-30]	SOLE	550,000	550,000
Alyeska Investment Group LP	[2025-06-30]	SOLE	500,000	500,000
Almitas Capital LLC	[2025-06-30]	SOLE	487,204	487,204
Morgan Stanley	[2025-06-30]	DFND	348,495	429,340
Citadel Advisors LLC	[2025-06-30]	DFND	413,056	413,056
Stonepine Capital Management LLC	[2025-06-30]	SOLE	310,033	310,033
Bank of America Corp /DE/	[2025-06-30]	DFND	7,088	308,660
Rangeley Capital LLC	[2025-06-30]	SOLE	302,080	302,080
Silver Point Capital LP	[2025-06-30]	DFND	290,000	290,000
Jane Street Group LLC	[2025-06-30]	DFND	163,299	279,299
Northern Trust Corp	[2025-06-30]	DFND	253,479	253,773
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	246,086	246,086
AQR Capital Management LLC	[2025-06-30]	DFND	231,145	231,149
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