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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	17,310,490	17,310,490
BlackRock, Inc.	[2025-06-30]	SOLE	3,465,747	3,579,442
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	2,055,707	2,055,707
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,796,491
Iconiq Capital LLC	[2025-06-30]	SOLE	0	1,266,563
TCG Crossover Management LLC	[2025-06-30]	SOLE	1,145,538	1,145,538
State Street Corp	[2025-06-30]	DFND	794,721	837,221
Geode Capital Management LLC	[2025-06-30]	DFND	789,682	789,682
Renaissance Technologies LLC	[2025-06-30]	SOLE	764,137	764,137
Boxer Capital Management LLC	[2025-06-30]	SOLE	0	750,000
Board of Trustees of The Leland Stanford Junior University	[2025-06-30]	SOLE	691,767	691,767
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	601,400	646,143
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	594,796	601,629
Ikarian Capital LLC	[2025-06-30]	SOLE	599,534	599,534
Nantahala Capital Management LLC	[2025-06-30]	SOLE	590,884	590,884
Point72 Asset Management LP	[2025-06-30]	DFND	0	452,696
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	394,291	420,705
SilverArc Capital Management LLC	[2025-06-30]	SOLE	401,540	401,540
Northern Trust Corp	[2025-06-30]	DFND	339,264	339,536
Bruce & Co Inc	[2025-06-30]	SOLE	323,000	323,000
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	271,823	271,823
Ameriprise Financial Inc	[2025-06-30]	DFND	0	266,354
FMR LLC	[2025-06-30]	DFND	246,520	252,269
Federated Hermes Inc	[2025-06-30]	DFND	244,231	244,231
Morgan Stanley	[2025-06-30]	DFND	124,207	243,620
Two Sigma Advisers LP	[2025-06-30]	SOLE	211,100	224,600
Goldman Sachs Group Inc	[2025-06-30]	DFND	198,871	199,011
GSA Capital Partners LLP	[2025-06-30]	SOLE	164,432	164,432
RIA Advisory Group LLC	[2025-06-30]	SOLE	0	163,465
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	161,264
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