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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Caligan Partners LP	[2025-06-30]	SOLE	8,118,892	8,118,892
BlackRock, Inc.	[2025-06-30]	SOLE	4,715,343	4,892,135
Farallon Capital Management LLC	[2025-06-30]	OTR	4,238,762	4,238,762
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,452,235
Findell Capital Management LLC	[2025-06-30]	SOLE	3,100,000	3,100,000
Opaleye Management Inc	[2025-06-30]	SOLE	2,475,000	2,475,000
Goldman Sachs Group Inc	[2025-06-30]	DFND	2,416,785	2,417,005
State Street Corp	[2025-06-30]	DFND	1,713,550	1,830,701
Susquehanna International Group LLP	[2025-06-30]	OTR	999,609	1,656,609
Janus Henderson Group PLC	[2025-06-30]	DFND	0	1,631,948
Deerfield Management Company LP	[2025-06-30]	DFND	1,616,778	1,616,778
Geode Capital Management LLC	[2025-06-30]	DFND	1,405,747	1,405,747
Whitefort Capital Management LP	[2025-06-30]	SOLE	1,331,602	1,331,602
TYRO Capital Management LLC	[2025-06-30]	SOLE	1,241,839	1,241,839
Hudson Bay Capital Management LP	[2025-06-30]	SOLE	1,188,556	1,188,556
Tang Capital Management LLC	[2025-06-30]	OTR	0	1,143,759
Centerbook Partners LP	[2025-06-30]	SOLE	1,103,850	1,103,850
Patient Square Capital LP	[2025-06-30]	SOLE	1,020,000	1,020,000
FMR LLC	[2025-06-30]	DFND	912,251	914,488
Shay Capital LLC	[2025-06-30]	SOLE	705,758	780,758
Citadel Advisors LLC	[2025-06-30]	DFND	766,451	766,451
Two Sigma Investments LP	[2025-06-30]	SOLE	746,998	746,998
Marshall Wace LLP	[2025-06-30]	OTR	0	660,762
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	658,888
Northern Trust Corp	[2025-06-30]	DFND	571,033	572,110
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	482,822
Mirabella Financial Services LLP	[2025-06-30]	SOLE	451,232	451,232
Morgan Stanley	[2025-06-30]	DFND	415,850	440,892
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	434,900	434,900
Woodline Partners LP	[2025-06-30]	SOLE	400,160	400,160
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