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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Flagship Pioneering Inc	[2023-03-31]	DFND	0.0	23,117,045.0
FMR LLC	[2023-03-31]	DFND	18,911,192.0	18,911,458.0
Federated Hermes Inc	[2023-03-31]	DFND	15,277,356.0	15,277,356.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	11,300,815.0
BlackRock Inc.	[2023-03-31]	SOLE	6,088,254.0	6,249,086.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	5,649,267.0
State Street Corp	[2023-03-31]	DFND	3,621,000.0	3,768,309.0
Eversept Partners LP	[2023-03-31]	SOLE	2,536,665.0	2,536,665.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,635,509.0	1,635,509.0
Avoro Capital Advisors LLC	[2023-03-31]	SOLE	1,295,000.0	1,295,000.0
Hudson Bay Capital Management LP	[2023-03-31]	SOLE	840,771.0	840,771.0
Handelsbanken Fonder AB	[2023-03-31]	SOLE	0.0	800,000.0
Kynam Capital Management LP	[2023-03-31]	SOLE	768,913.0	768,913.0
Northern Trust Corp	[2023-03-31]	DFND	67,929.0	740,490.0
Jennison Associates LLC	[2023-03-31]	DFND	664,734.0	664,734.0
Citadel Advisors LLC	[2023-03-31]	DFND	657,593.0	657,593.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	633,869.0	633,869.0
JPMorgan Chase & Co	[2023-03-31]	DFND	499.0	621,355.0
Lion Point Capital LP	[2023-03-31]	SOLE	596,803.0	596,803.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	550,819.0	550,819.0
Simplify Asset Management Inc	[2023-03-31]	SOLE	550,626.0	550,626.0
Citigroup Inc	[2023-03-31]	DFND	450,822.0	450,822.0
Millennium Management LLC	[2023-03-31]	SOLE	408,480.0	408,480.0
Bank of America Corp /DE/	[2023-03-31]	DFND	17,916.0	407,197.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	398,200.0	398,200.0
Susquehanna International Group LLP	[2023-03-31]	DFND	294,446.0	383,546.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	369,695.0	369,695.0
Walleye Capital LLC	[2023-03-31]	SOLE	362,324.0	362,324.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	297,835.0	320,748.0
Knott David M Jr	[2023-03-31]	DFND	315,000.0	315,000.0
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