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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Tang Capital Management LLC	[2023-03-31]	OTR	0.0	6,050,000.0
Lion Point Capital LP	[2023-03-31]	SOLE	4,558,466.0	4,558,466.0
Atlas Venture Life Science Advisors LLC	[2023-03-31]	SOLE	3,791,698.0	3,791,698.0
Alphabet Inc.	[2023-03-31]	DFND	0.0	3,339,138.0
Verition Fund Management LLC	[2023-03-31]	SOLE	2,198,465.0	2,198,465.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,955,378.0
Western Standard LLC	[2023-03-31]	SOLE	1,439,374.0	1,439,374.0
TCW Group Inc	[2023-03-31]	DFND	750,000.0	750,000.0
Acadian Asset Management LLC	[2023-03-31]	DFND	614,213.0	614,213.0
Laurion Capital Management LP	[2023-03-31]	SOLE	582,300.0	582,300.0
Morgan Stanley	[2023-03-31]	DFND	515,789.0	517,039.0
BlackRock Inc.	[2023-03-31]	SOLE	464,210.0	465,969.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	393,400.0	393,400.0
Geode Capital Management LLC	[2023-03-31]	DFND	357,690.0	357,690.0
Harvard Management Co Inc	[2023-03-31]	SOLE	332,610.0	332,610.0
RBF Capital, LLC	[2023-03-31]	SOLE	250,822.0	250,822.0
Bessemer Group Inc	[2023-03-31]	DFND	237,292.0	237,292.0
Credit Suisse AG	[2023-03-31]	DFND	193,500.0	193,500.0
Susquehanna International Group LLP	[2023-03-31]	DFND	181,503.0	181,503.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	157,670.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	140,245.0	154,054.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	152,700.0	152,700.0
Harbor Capital Advisors Inc	[2023-03-31]	SOLE	152,138.0	152,138.0
State Street Corp	[2023-03-31]	DFND	139,207.0	139,207.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	97,335.0
Two Sigma Investments LP	[2023-03-31]	SOLE	91,373.0	91,373.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	65,321.0	65,321.0
Cheyne Capital Management UK LLP	[2023-03-31]	SOLE	47,170.0	47,170.0
Corsair Capital Management LP	[2023-03-31]	SOLE	32,846.0	32,846.0
Citadel Advisors LLC	[2023-03-31]	DFND	30,620.0	30,620.0
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