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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	3,595,788	3,595,788
AIGH Capital Management LLC	[2025-06-30]	SOLE	2,679,986	2,679,986
BlackRock, Inc.	[2025-06-30]	SOLE	1,648,029	1,675,827
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,445,433
Journey Advisory Group LLC	[2025-06-30]	SOLE	0	875,844
AIGH Capital Management LLC	[2025-06-30]	OTR	0	875,756
Soleus Capital Management LP	[2025-06-30]	SOLE	704,275	704,275
Geode Capital Management LLC	[2025-06-30]	DFND	669,281	669,281
Renaissance Technologies LLC	[2025-06-30]	SOLE	541,405	541,405
Stonepine Capital Management LLC	[2025-06-30]	SOLE	457,419	457,419
Morgan Stanley	[2025-06-30]	DFND	434,372	445,495
Clearstead Advisors LLC	[2025-06-30]	SOLE	0	425,589
Goldman Sachs Group Inc	[2025-06-30]	DFND	367,084	367,084
Citadel Advisors LLC	[2025-06-30]	DFND	352,490	352,490
State Street Corp	[2025-06-30]	DFND	307,201	341,825
Marshall Wace LLP	[2025-06-30]	OTR	0	304,400
Thompson Siegel & Walmsley LLC	[2025-06-30]	DFND	285,655	285,655
Northern Trust Corp	[2025-06-30]	DFND	230,482	230,482
Millennium Management LLC	[2025-06-30]	SOLE	229,443	229,443
Essex Investment Management Co LLC	[2025-06-30]	SOLE	101,825	200,000
UBS Group AG	[2025-06-30]	DFND	190,598	190,598
Two Sigma Investments LP	[2025-06-30]	SOLE	151,755	151,755
JPMorgan Chase & Co	[2025-06-30]	DFND	121,923	137,307
Nuveen, LLC	[2025-06-30]	DFND	119,681	119,681
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	103,061	103,061
Huntleigh Advisors Inc	[2025-06-30]	SOLE	100,704	100,704
Aristides Capital LLC	[2025-06-30]	SOLE	95,000	95,000
Squarepoint Ops LLC	[2025-06-30]	DFND	0	92,606
Jump Financial, LLC	[2025-06-30]	DFND	87,000	87,000
Jane Street Group LLC	[2025-06-30]	DFND	83,156	83,156
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