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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	10,805,129	10,805,129
Tang Capital Management LLC	[2025-06-30]	OTR	0	7,055,576
BlackRock, Inc.	[2025-06-30]	SOLE	4,055,300	4,153,845
Samsara Biocapital LLC	[2025-06-30]	SOLE	3,768,035	3,768,035
NEA Management Company LLC	[2025-06-30]	DFND	3,568,781	3,568,781
Citadel Advisors LLC	[2025-06-30]	DFND	3,348,224	3,348,224
SR One Capital Management LP	[2025-06-30]	SOLE	3,333,333	3,333,333
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,513,882
Alyeska Investment Group LP	[2025-06-30]	SOLE	2,084,696	2,084,696
Wasatch Advisors LP	[2025-06-30]	SOLE	1,786,214	1,786,214
Monaco Asset Management SAM	[2025-06-30]	SOLE	1,583,372	1,583,372
Geode Capital Management LLC	[2025-06-30]	DFND	1,208,378	1,208,378
State Street Corp	[2025-06-30]	DFND	1,072,968	1,137,942
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	800,000	800,000
Blackstone Inc.	[2025-06-30]	OTR	0	747,044
Bank of America Corp /DE/	[2025-06-30]	DFND	18,836	742,718
AWM Investment Company Inc	[2025-06-30]	SOLE	700,000	700,000
Renaissance Technologies LLC	[2025-06-30]	SOLE	696,372	696,372
Peapod Lane Capital LLC	[2025-06-30]	SOLE	530,072	663,850
Goldman Sachs Group Inc	[2025-06-30]	DFND	593,799	593,799
JPMorgan Chase & Co	[2025-06-30]	DFND	552,737	578,012
Woodline Partners LP	[2025-06-30]	SOLE	500,166	500,166
Acadian Asset Management LLC	[2025-06-30]	DFND	475,887	475,887
Northern Trust Corp	[2025-06-30]	DFND	453,790	453,790
AQR Capital Management LLC	[2025-06-30]	DFND	440,255	440,255
Royal Bank of Canada	[2025-06-30]	DFND	402,016	402,016
Morgan Stanley	[2025-06-30]	DFND	289,585	323,625
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	235,160	286,688
Barclays PLC	[2025-06-30]	SOLE	280,312	280,312
Two Sigma Investments LP	[2025-06-30]	SOLE	271,962	271,962
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