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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2023-03-31]	SOLE	0.0	7,805,129.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	1,965,072.0	5,177,788.0
Wasatch Advisors LP	[2023-03-31]	SOLE	3,343,083.0	3,913,676.0
NEA Management Company LLC	[2023-03-31]	DFND	3,568,781.0	3,568,781.0
BlackRock Inc.	[2023-03-31]	SOLE	3,072,917.0	3,221,996.0
Samsara Biocapital LLC	[2023-03-31]	SOLE	2,868,035.0	2,868,035.0
Tang Capital Management LLC	[2023-03-31]	OTR	0.0	1,785,829.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,503,325.0
Deep Track Capital LP	[2023-03-31]	SOLE	1,354,200.0	1,354,200.0
SR One Capital Management LP	[2023-03-31]	SOLE	1,333,333.0	1,333,333.0
Laurion Capital Management LP	[2023-03-31]	SOLE	1,197,060.0	1,197,060.0
Geode Capital Management LLC	[2023-03-31]	DFND	643,196.0	643,196.0
State Street Corp	[2023-03-31]	DFND	548,838.0	582,412.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	488,323.0	488,323.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	400,000.0	400,000.0
Barclays PLC	[2023-03-31]	SOLE	395,047.0	395,047.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	393,389.0	393,389.0
JPMorgan Chase & Co	[2023-03-31]	DFND	364,262.0	389,358.0
Northern Trust Corp	[2023-03-31]	DFND	1,551.0	272,896.0
Susquehanna International Group LLP	[2023-03-31]	DFND	254,609.0	270,209.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	243,300.0	243,300.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	240,330.0	240,330.0
Prudential Financial Inc	[2023-03-31]	DFND	97,480.0	218,580.0
Rhenman & Partners Asset Management AB	[2023-03-31]	SOLE	0.0	200,000.0
Stifel Financial Corp	[2023-03-31]	DFND	162,786.0	174,886.0
Morgan Stanley	[2023-03-31]	DFND	163,365.0	171,544.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	150,000.0	150,000.0
ExodusPoint Capital Management LP	[2023-03-31]	SOLE	136,700.0	136,700.0
New York Life Investment Management LLC	[2023-03-31]	SOLE	134,592.0	134,592.0
Two Sigma Investments LP	[2023-03-31]	SOLE	130,279.0	130,279.0
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