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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Sofinnova Investments Inc	[2025-06-30]	SOLE	2,671,856	2,671,856
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	2,302,598	2,302,598
Citigroup Inc	[2025-06-30]	DFND	1,025,469	1,025,469
Vanguard Group Inc	[2025-06-30]	SOLE	0	872,020
Cable Car Capital LP	[2025-06-30]	SOLE	758,141	758,141
Renaissance Technologies LLC	[2025-06-30]	SOLE	500,935	500,935
Acadian Asset Management LLC	[2025-06-30]	DFND	488,440	488,440
BlackRock, Inc.	[2025-06-30]	SOLE	362,365	376,025
Cardiff Park Advisors LLC	[2025-06-30]	SOLE	0	262,000
Geode Capital Management LLC	[2025-06-30]	DFND	229,707	229,707
Macquarie Group Ltd	[2025-06-30]	SOLE	150,000	150,000
SIO Capital Management LLC	[2025-06-30]	SOLE	131,300	131,300
Pfizer Inc	[2025-06-30]	DFND	0	131,109
Adar1 Capital Management LLC	[2025-06-30]	SOLE	118,012	118,012
Armistice Capital LLC	[2025-06-30]	SOLE	104,000	104,000
Barclays PLC	[2025-06-30]	SOLE	67,518	67,518
State Street Corp	[2025-06-30]	DFND	65,392	65,392
Citadel Advisors LLC	[2025-06-30]	DFND	58,845	58,845
Northern Trust Corp	[2025-06-30]	DFND	47,493	47,493
Velan Capital Investment Management LP	[2025-06-30]	SOLE	45,000	45,000
IEQ Capital LLC	[2025-06-30]	SOLE	0	37,342
Susquehanna International Group LLP	[2025-06-30]	OTR	29,503	29,503
Pfizer Inc	[2025-06-30]	SOLE	26,537	26,537
HSBC Holdings PLC	[2025-06-30]	DFND	17,257	17,257
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	13,835	13,835
UBS Group AG	[2025-06-30]	DFND	8,219	12,299
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	1,528	1,528
Osaic Holdings Inc	[2025-06-30]	DFND	0	1,191
Simplex Trading LLC	[2025-06-30]	SOLE	920	920
JPMorgan Chase & Co	[2025-06-30]	DFND	756	756
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