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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Broadwood Capital Inc	[2023-03-31]	DFND	23,353,697.0	23,353,697.0
Pura Vida Investments LLC	[2023-03-31]	SOLE	14,166,163.0	14,166,163.0
AWM Investment Company Inc	[2023-03-31]	SOLE	6,773,051.0	6,773,051.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	4,312,761.0
Defender Capital LLC	[2023-03-31]	SOLE	2,363,430.0	2,363,430.0
BlackRock Inc.	[2023-03-31]	SOLE	1,421,787.0	1,425,386.0
Geode Capital Management LLC	[2023-03-31]	DFND	992,454.0	992,454.0
Millennium Management LLC	[2023-03-31]	SOLE	474,711.0	474,711.0
State Street Corp	[2023-03-31]	DFND	281,845.0	281,845.0
Penbrook Management LLC	[2023-03-31]	SOLE	0.0	207,675.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	205,300.0	205,300.0
Northern Trust Corp	[2023-03-31]	DFND	270.0	194,911.0
LPL Financial LLC	[2023-03-31]	SOLE	0.0	147,563.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	63,107.0	63,107.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	62,284.0	62,284.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	59,600.0	59,600.0
Vanguard Group Inc	[2023-03-31]	DFND	0.0	46,441.0
Ameriprise Financial Inc	[2023-03-31]	DFND	0.0	42,400.0
Wealth Effects LLC	[2023-03-31]	SOLE	0.0	40,500.0
Tower Research Capital LLC (TRC)	[2023-03-31]	DFND	38,236.0	38,236.0
Morgan Stanley	[2023-03-31]	DFND	302.0	36,534.0
Susquehanna International Group LLP	[2023-03-31]	DFND	34,776.0	34,776.0
Deutsche Bank AG	[2023-03-31]	DFND	33,890.0	33,890.0
Merit Financial Group LLC	[2023-03-31]	SOLE	0.0	32,000.0
Lee Danner & Bass Inc	[2023-03-31]	SOLE	0.0	27,763.0
Bank of America Corp /DE/	[2023-03-31]	DFND	4,200.0	26,288.0
Jane Street Group LLC	[2023-03-31]	DFND	24,806.0	24,806.0
Advisor Group Holdings Inc	[2023-03-31]	SOLE	0.0	21,610.0
Schonfeld Strategic Advisors LLC	[2023-03-31]	SOLE	21,500.0	21,500.0
Westshore Wealth LLC	[2023-03-31]	SOLE	0.0	20,000.0
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