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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RTW Investments LP	[2025-06-30]	SOLE	17,687,772	17,687,772
Maverick Capital Ltd	[2025-06-30]	SOLE	8,363,813	8,363,813
BlackRock, Inc.	[2025-06-30]	SOLE	7,158,020	7,428,676
Vanguard Group Inc	[2025-06-30]	SOLE	0	5,958,370
Suvretta Capital Management LLC	[2025-06-30]	SOLE	4,143,333	4,143,333
MPM BioImpact LLC	[2025-06-30]	SOLE	3,903,081	3,903,081
Morgan Stanley	[2025-06-30]	DFND	2,954,245	3,169,036
Millennium Management LLC	[2025-06-30]	SOLE	2,348,837	2,348,837
Geode Capital Management LLC	[2025-06-30]	DFND	2,030,891	2,030,891
Newtyn Management LLC	[2025-06-30]	SOLE	2,000,000	2,000,000
State Street Corp	[2025-06-30]	DFND	1,738,894	1,943,690
Two Sigma Investments LP	[2025-06-30]	SOLE	1,725,360	1,725,360
ProSight Management LP	[2025-06-30]	SOLE	1,580,588	1,580,588
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,574,773	1,575,468
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	1,548,262	1,548,262
Two Sigma Advisers LP	[2025-06-30]	SOLE	1,432,306	1,490,251
JPMorgan Chase & Co	[2025-06-30]	DFND	1,127,212	1,205,841
Toronto Dominion Bank	[2025-06-30]	DFND	0	1,100,000
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	1,016,849	1,016,849
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	992,825	992,825
Tang Capital Management LLC	[2025-06-30]	OTR	0	850,000
UBS Group AG	[2025-06-30]	DFND	811,308	836,508
AQR Capital Management LLC	[2025-06-30]	DFND	658,719	754,820
Susquehanna International Group LLP	[2025-06-30]	OTR	152,238	726,138
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	718,781
Northern Trust Corp	[2025-06-30]	DFND	687,829	688,689
Woodline Partners LP	[2025-06-30]	SOLE	652,865	652,865
Nuveen, LLC	[2025-06-30]	DFND	638,515	638,515
Federated Hermes Inc	[2025-06-30]	DFND	624,303	624,303
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	614,761	614,761
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