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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
QVT Financial LP	[2023-03-31]	DFND	122,541,536.0	122,541,536.0
Viking Global Investors LP	[2023-03-31]	SOLE	88,238,700.0	88,238,700.0
SB Investment Advisers UK Ltd	[2023-03-31]	DFND	0.0	83,031,667.0
FMR LLC	[2023-03-31]	DFND	30,762,284.0	30,762,284.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	14,880,925.0	14,880,925.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	12,028,797.0
State Street Corp	[2023-03-31]	DFND	7,886,152.0	8,032,952.0
Two SEAS Capital LP	[2023-03-31]	SOLE	7,807,107.0	7,807,107.0
Patient Square Capital LP	[2023-03-31]	SOLE	6,825,967.0	6,825,967.0
BlackRock Inc.	[2023-03-31]	SOLE	6,020,208.0	6,202,609.0
Rubric Capital Management LP	[2023-03-31]	SOLE	5,600,000.0	5,600,000.0
Anchorage Capital Group LLC	[2023-03-31]	SOLE	4,832,642.0	4,832,642.0
Baker Bros Advisors LP	[2023-03-31]	SOLE	4,777,430.0	4,777,430.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	4,761,438.0
Octagon Capital Advisors LP	[2023-03-31]	SOLE	3,904,000.0	3,904,000.0
SC CHINA HOLDING Ltd	[2023-03-31]	DFND	3,897,193.0	3,897,193.0
Woodline Partners LP	[2023-03-31]	SOLE	3,560,551.0	3,560,551.0
Morgan Stanley	[2023-03-31]	DFND	3,172,422.0	3,176,264.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	2,692,136.0	2,692,136.0
American International Group Inc	[2023-03-31]	SOLE	1,814,697.0	1,814,697.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	1,775,186.0	1,775,191.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	1,750,000.0	1,750,000.0
Eventide Asset Management LLC	[2023-03-31]	SOLE	1,690,300.0	1,690,300.0
Franklin Resources Inc	[2023-03-31]	DFND	1,625,050.0	1,625,050.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,621,443.0	1,621,443.0
RTW Investments LP	[2023-03-31]	SOLE	1,552,717.0	1,552,717.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,522,699.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,470,640.0	1,470,640.0
Two Sigma Investments LP	[2023-03-31]	SOLE	1,219,917.0	1,219,917.0
Founders Fund VI Management, LLC	[2023-03-31]	SOLE	1,119,489.0	1,119,489.0
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