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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
SB Investment Advisers UK Ltd	[2025-06-30]	SOLE	59,952,652	59,952,652
FMR LLC	[2025-06-30]	DFND	55,467,163	55,509,281
Morgan Stanley	[2025-06-30]	DFND	41,230,847	44,693,966
BlackRock, Inc.	[2025-06-30]	SOLE	38,762,920	40,316,307
Vanguard Group Inc	[2025-06-30]	SOLE	0	38,707,302
Viking Global Investors LP	[2025-06-30]	SOLE	34,237,779	34,237,779
QVT Financial LP	[2025-06-30]	DFND	29,381,635	29,381,635
Rubric Capital Management LP	[2025-06-30]	SOLE	20,370,336	20,370,336
State Street Corp	[2025-06-30]	DFND	18,680,617	19,773,480
Patient Square Capital LP	[2025-06-30]	SOLE	12,480,000	12,480,000
Two SEAS Capital LP	[2025-06-30]	SOLE	10,598,040	10,598,040
Geode Capital Management LLC	[2025-06-30]	DFND	7,674,062	7,750,399
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	6,061,112	6,644,869
UBS Group AG	[2025-06-30]	DFND	5,092,598	5,093,068
Anchorage Capital Group LLC	[2025-06-30]	SOLE	4,832,642	4,832,642
Blackbarn Capital Partners LP	[2025-06-30]	SOLE	4,625,000	4,625,000
Bank of New York Mellon Corp	[2025-06-30]	DFND	4,263,176	4,503,095
Sofinnova Investments Inc	[2025-06-30]	SOLE	4,088,814	4,088,814
Woodline Partners LP	[2025-06-30]	SOLE	4,000,033	4,000,033
Whitefort Capital Management LP	[2025-06-30]	SOLE	3,882,000	3,882,000
Baker Bros Advisors LP	[2025-06-30]	SOLE	3,767,773	3,767,773
DME Capital Management LP	[2025-06-30]	SOLE	3,371,387	3,371,387
Toms Capital Investment Management LP	[2025-06-30]	SOLE	3,180,800	3,340,000
Perceptive Advisors LLC	[2025-06-30]	SOLE	3,331,465	3,331,465
Pertento Partners LLP	[2025-06-30]	SOLE	3,104,361	3,104,361
Northern Trust Corp	[2025-06-30]	DFND	3,008,902	3,027,978
Point72 Asset Management LP	[2025-06-30]	DFND	0	2,951,132
Goldman Sachs Group Inc	[2025-06-30]	DFND	2,867,099	2,937,367
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	2,889,045	2,889,082
OrbiMed Advisors LLC	[2025-06-30]	DFND	439,129	2,779,427
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