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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Federated Hermes Inc	[2023-03-31]	DFND	6,610,274.0	6,610,274.0
First Manhattan Co LLC	[2023-03-31]	SOLE	3,123,078.0	3,123,078.0
Stonepine Capital Management LLC	[2023-03-31]	SOLE	3,087,649.0	3,087,649.0
Blackstone Inc.	[2023-03-31]	OTR	0.0	1,537,684.0
Caxton Corp	[2023-03-31]	SOLE	1,403,157.0	1,403,157.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,396,121.0
Sphera Funds Management Ltd	[2023-03-31]	DFND	1,155,897.0	1,155,897.0
Commodore Capital LP	[2023-03-31]	SOLE	898,267.0	898,267.0
Nantahala Capital Management LLC	[2023-03-31]	SOLE	769,606.0	769,606.0
CVI Holdings, LLC	[2023-03-31]	DFND	634,533.0	634,533.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	631,690.0	631,690.0
Vivo Capital LLC	[2023-03-31]	SOLE	489,473.0	489,473.0
UBS OConnor LLC	[2023-03-31]	DFND	430,475.0	430,475.0
Velan Capital Investment Management LP	[2023-03-31]	SOLE	400,000.0	400,000.0
Acuta Capital Partners LLC	[2023-03-31]	SOLE	366,204.0	366,204.0
Citadel Advisors LLC	[2023-03-31]	DFND	340,837.0	340,837.0
BlackRock Inc.	[2023-03-31]	SOLE	257,663.0	258,639.0
Geode Capital Management LLC	[2023-03-31]	DFND	250,876.0	250,876.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	190,815.0
Northern Trust Corp	[2023-03-31]	DFND	1,000.0	74,799.0
State Street Corp	[2023-03-31]	DFND	56,172.0	56,172.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	26,988.0	26,988.0
FMR LLC	[2023-03-31]	DFND	20,200.0	20,200.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	19,400.0	19,400.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	13,757.0	13,757.0
Boothbay Fund Management LLC	[2023-03-31]	OTR	0.0	12,000.0
AIGH Capital Management LLC	[2023-03-31]	SOLE	11,866.0	11,866.0
Vanguard Group Inc	[2023-03-31]	DFND	0.0	11,531.0
Morgan Stanley	[2023-03-31]	DFND	0.0	2,071.0
UBS Group AG	[2023-03-31]	SOLE	2,056.0	2,056.0
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