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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
OrbiMed Advisors LLC	[2025-06-30]	SOLE	6,059,528	6,059,528
Rubric Capital Management LP	[2025-06-30]	SOLE	4,601,977	4,601,977
King Luther Capital Management Corp	[2025-06-30]	SOLE	3,541,170	3,541,170
AIGH Capital Management LLC	[2025-06-30]	SOLE	2,900,267	2,900,267
BlackRock, Inc.	[2025-06-30]	SOLE	2,172,016	2,211,316
Morgan Stanley	[2025-06-30]	DFND	1,883,815	2,147,886
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,784,189
Rice Hall James & Associates LLC	[2025-06-30]	SOLE	1,380,701	1,472,527
5AM Venture Management LLC	[2025-06-30]	SOLE	1,200,647	1,200,647
Nantahala Capital Management LLC	[2025-06-30]	SOLE	995,438	995,438
AIGH Capital Management LLC	[2025-06-30]	OTR	0	967,256
Velan Capital Investment Management LP	[2025-06-30]	SOLE	917,668	917,668
UBS Group AG	[2025-06-30]	DFND	855,302	855,302
State Street Corp	[2025-06-30]	DFND	759,794	805,009
APIS Capital Advisors LLC	[2025-06-30]	SOLE	752,000	752,000
Geode Capital Management LLC	[2025-06-30]	DFND	749,484	749,484
Diadema Partners LP	[2025-06-30]	SOLE	704,123	704,123
Kingdon Capital Management LLC	[2025-06-30]	DFND	659,711	659,711
Millennium Management LLC	[2025-06-30]	SOLE	538,470	538,470
Royal Bank of Canada	[2025-06-30]	DFND	503,705	503,705
Perceptive Advisors LLC	[2025-06-30]	SOLE	500,000	500,000
Tejara Capital Ltd	[2025-06-30]	SOLE	497,730	497,730
Susquehanna International Group LLP	[2025-06-30]	OTR	138,460	279,860
Northern Trust Corp	[2025-06-30]	DFND	277,237	277,237
Nomura Holdings Inc	[2025-06-30]	DFND	169,272	169,272
Citadel Advisors LLC	[2025-06-30]	DFND	130,075	130,075
J Goldman & Co LP	[2025-06-30]	SOLE	121,500	121,500
Goldman Sachs Group Inc	[2025-06-30]	DFND	101,888	101,888
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	94,809	94,809
Balanced Rock Investment Advisors LLC	[2025-06-30]	SOLE	0	90,968
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