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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Lombard Odier Asset Management USA Corp	[2023-03-31]	OTR	3,959,101.0	3,959,101.0
Lombard Odier Asset Management (Europe) Ltd	[2023-03-31]	OTR	3,293,405.0	3,293,405.0
TCG Crossover Management LLC	[2023-03-31]	SOLE	2,104,875.0	2,104,875.0
Deep Track Capital LP	[2023-03-31]	SOLE	1,951,580.0	1,951,580.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	1,508,416.0
Aquilo Capital Management LLC	[2023-03-31]	SOLE	1,312,233.0	1,312,233.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	881,173.0	881,173.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	660,000.0	660,000.0
AXA Sa	[2023-03-31]	DFND	516,416.0	516,416.0
Artal Group S.A.	[2023-03-31]	DFND	505,074.0	505,074.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	349,462.0
Cantor Fitzgerald L P	[2023-03-31]	DFND	0.0	289,158.0
HSBC Holdings PLC	[2023-03-31]	DFND	177,834.0	177,834.0
Parkman Healthcare Partners LLC	[2023-03-31]	SOLE	158,774.0	158,774.0
M28 Capital Management LP	[2023-03-31]	SOLE	145,900.0	145,900.0
Woodline Partners LP	[2023-03-31]	SOLE	143,684.0	143,684.0
UBS OConnor LLC	[2023-03-31]	DFND	95,383.0	95,383.0
Morgan Stanley	[2023-03-31]	DFND	72,677.0	72,677.0
UBS Group AG	[2023-03-31]	SOLE	69,006.0	69,006.0
Citigroup Inc	[2023-03-31]	DFND	58,333.0	58,333.0
Blair William & Co/IL	[2023-03-31]	SOLE	41,263.0	41,263.0
Schonfeld Strategic Advisors LLC	[2023-03-31]	SOLE	41,100.0	41,100.0
WS Management LLLP	[2023-03-31]	SOLE	25,000.0	25,000.0
Millennium Management LLC	[2023-03-31]	SOLE	19,684.0	19,684.0
Geode Capital Management LLC	[2023-03-31]	DFND	14,687.0	14,687.0
Cubist Systematic Strategies, LLC	[2023-03-31]	DFND	0.0	2,600.0
Deutsche Bank AG	[2023-03-31]	DFND	620.0	620.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	550.0
Steward Partners Investment Advisory LLC	[2023-03-31]	SOLE	0.0	100.0
Concourse Financial Group Securities Inc	[2023-03-31]	SOLE	0.0	0.0
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