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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Column Group LLC	[2025-06-30]	SOLE	1,499,773	1,499,773
Stempoint Capital LP	[2025-06-30]	SOLE	633,475	686,539
VR Adviser LLC	[2025-06-30]	SOLE	632,931	632,931
RA Capital Management LP	[2025-06-30]	SOLE	602,626	602,626
5AM Venture Management LLC	[2025-06-30]	SOLE	310,000	310,000
Stonepine Capital Management LLC	[2025-06-30]	SOLE	306,029	306,029
Vivo Capital LLC	[2025-06-30]	SOLE	260,000	260,000
Samsara Biocapital LLC	[2025-06-30]	SOLE	241,400	241,400
Nantahala Capital Management LLC	[2025-06-30]	SOLE	229,527	229,527
Vanguard Group Inc	[2025-06-30]	SOLE	0	218,520
Acuta Capital Partners LLC	[2025-06-30]	SOLE	170,000	170,000
Braidwell LP	[2025-06-30]	SOLE	140,000	140,000
Regents of the University of California	[2025-06-30]	SOLE	133,207	133,207
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	88,653	88,653
Euclidean Capital LLC	[2025-06-30]	SOLE	87,696	87,696
Driehaus Capital Management LLC	[2025-06-30]	SOLE	67,566	67,566
Armistice Capital LLC	[2025-06-30]	SOLE	60,000	60,000
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	55,123	55,123
Board of Trustees of The Leland Stanford Junior University	[2025-06-30]	SOLE	52,130	52,130
Trustees of Columbia University in the City of New York	[2025-06-30]	SOLE	47,930	47,930
Morgan Stanley	[2025-06-30]	DFND	34,431	34,764
Geode Capital Management LLC	[2025-06-30]	DFND	30,963	30,963
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	21,715	21,715
BlackRock, Inc.	[2025-06-30]	SOLE	15,483	15,483
Renaissance Technologies LLC	[2025-06-30]	SOLE	14,626	14,626
Citadel Advisors LLC	[2025-06-30]	DFND	10,451	10,451
Alyeska Investment Group LP	[2025-06-30]	SOLE	10,188	10,188
Vanguard Group Inc	[2025-06-30]	DFND	0	430
Wolverine Asset Management LLC	[2025-06-30]	DFND	281	281
UBS Group AG	[2025-06-30]	DFND	259	259
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