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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baker Bros Advisors LP	[2025-06-30]	SOLE	833,333	833,333
LMR Partners LLP	[2025-06-30]	SOLE	648,285	648,285
Bridger Management LLC	[2025-06-30]	SOLE	442,052	442,052
Euclidean Capital LLC	[2025-06-30]	SOLE	170,833	170,833
Deerfield Management Company LP	[2025-06-30]	DFND	166,666	166,666
Perceptive Advisors LLC	[2025-06-30]	SOLE	166,666	166,666
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	108,333	108,333
Samsara Biocapital LLC	[2025-06-30]	SOLE	99,999	99,999
Regents of the University of California	[2025-06-30]	SOLE	83,333	83,333
Millennium Management LLC	[2025-06-30]	SOLE	0	73,900
Cantor Fitzgerald L P	[2025-06-30]	DFND	0	70,824
Boxer Capital Management LLC	[2025-06-30]	SOLE	0	66,666
EcoR1 Capital LLC	[2025-06-30]	SOLE	66,665	66,665
Price T Rowe Associates Inc /MD/	[2025-06-30]	SOLE	41,666	41,666
Trustees of Columbia University in the City of New York	[2025-06-30]	SOLE	33,333	33,333
Monashee Investment Management LLC	[2025-06-30]	SOLE	30,129	30,129
Hudson Bay Capital Management LP	[2025-06-30]	SOLE	20,718	20,718
UBS Group AG	[2025-06-30]	DFND	1,440	1,440
Clear Street LLC	[2025-06-30]	SOLE	100	100
Toronto Dominion Bank	[2025-06-30]	DFND	0	100
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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