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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Suvretta Capital Management LLC	[2023-03-31]	SOLE	5,689,086.0	5,689,086.0
BlackRock Inc.	[2023-03-31]	SOLE	4,798,305.0	5,020,823.0
Rubric Capital Management LP	[2023-03-31]	SOLE	4,360,487.0	4,360,487.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	3,347,946.0
State Street Corp	[2023-03-31]	DFND	2,865,212.0	2,922,712.0
Franklin Resources Inc	[2023-03-31]	DFND	2,837,018.0	2,837,869.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	2,722,697.0
Holocene Advisors LP	[2023-03-31]	SOLE	2,132,873.0	2,132,873.0
Candriam SCA	[2023-03-31]	SOLE	1,860,694.0	1,860,694.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	1,776,479.0	1,776,479.0
Samsara Biocapital LLC	[2023-03-31]	SOLE	1,675,579.0	1,675,579.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	1,488,487.0	1,488,487.0
Verition Fund Management LLC	[2023-03-31]	SOLE	1,145,786.0	1,145,786.0
Baillie Gifford & Co	[2023-03-31]	DFND	1,116,928.0	1,116,928.0
Parkman Healthcare Partners LLC	[2023-03-31]	SOLE	1,100,038.0	1,100,038.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	1,004,388.0	1,075,703.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,056,314.0	1,056,314.0
Kynam Capital Management LP	[2023-03-31]	SOLE	901,836.0	901,836.0
Millennium Management LLC	[2023-03-31]	SOLE	891,616.0	891,616.0
Baillie Gifford & Co	[2023-03-31]	SOLE	750,726.0	750,726.0
Acadian Asset Management LLC	[2023-03-31]	DFND	687,235.0	687,235.0
Jacobs Levy Equity Management Inc	[2023-03-31]	SOLE	589,119.0	664,601.0
Northern Trust Corp	[2023-03-31]	DFND	10,819.0	454,907.0
PanAgora Asset Management Inc	[2023-03-31]	SOLE	149,039.0	431,982.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	364,800.0	421,300.0
AQR Capital Management LLC	[2023-03-31]	DFND	328,750.0	393,696.0
Schonfeld Strategic Advisors LLC	[2023-03-31]	SOLE	345,996.0	345,996.0
Two Sigma Investments LP	[2023-03-31]	SOLE	340,412.0	340,412.0
Citadel Advisors LLC	[2023-03-31]	DFND	330,768.0	330,768.0
Bank of America Corp /DE/	[2023-03-31]	DFND	8,821.0	315,297.0
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