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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
NEA Management Company LLC	[2025-06-30]	DFND	24,471,264	24,471,264
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	17,600,621	17,600,621
TCG Crossover Management LLC	[2025-06-30]	SOLE	12,362,205	12,362,205
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	11,462,301	11,462,301
Vestal Point Capital LP	[2025-06-30]	SOLE	11,015,000	11,015,000
BlackRock, Inc.	[2025-06-30]	SOLE	9,571,532	9,775,573
VR Adviser LLC	[2025-06-30]	SOLE	8,884,263	8,884,263
Nantahala Capital Management LLC	[2025-06-30]	SOLE	8,325,375	8,325,375
Vanguard Group Inc	[2025-06-30]	SOLE	0	8,221,994
Deerfield Management Company LP	[2025-06-30]	DFND	7,964,000	7,964,000
Farallon Capital Management LLC	[2025-06-30]	OTR	6,835,000	6,835,000
Adar1 Capital Management LLC	[2025-06-30]	SOLE	3,600,670	3,600,670
Emerald Advisers LLC	[2025-06-30]	SOLE	2,615,409	3,534,368
Wellington Management Group LLP	[2025-06-30]	DFND	0	3,350,272
Geode Capital Management LLC	[2025-06-30]	DFND	2,970,183	2,970,183
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	2,654,944	2,654,944
Sofinnova Investments Inc	[2025-06-30]	SOLE	2,457,352	2,457,352
State Street Corp	[2025-06-30]	DFND	2,278,445	2,456,941
Emerald Mutual Fund Advisers Trust	[2025-06-30]	SOLE	2,186,404	2,186,404
Sphera Funds Management Ltd	[2025-06-30]	DFND	1,310,233	1,310,233
Superstring Capital Management LP	[2025-06-30]	SOLE	1,115,379	1,115,379
Northern Trust Corp	[2025-06-30]	DFND	1,051,841	1,051,841
AXA Sa	[2025-06-30]	DFND	1,050,126	1,050,126
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	995,511	995,511
Deutsche Bank AG	[2025-06-30]	DFND	622,979	831,045
Voya Investment Management LLC	[2025-06-30]	DFND	0	797,118
SIO Capital Management LLC	[2025-06-30]	SOLE	726,851	726,851
GSA Capital Partners LLP	[2025-06-30]	SOLE	708,463	708,463
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	504,383	601,037
Goldman Sachs Group Inc	[2025-06-30]	DFND	530,078	530,078
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