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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	9,053,034	9,053,034
Fairmount Funds Management LLC	[2025-06-30]	SOLE	4,018,101	4,018,101
BlackRock, Inc.	[2025-06-30]	SOLE	3,905,236	4,007,296
RTW Investments LP	[2025-06-30]	SOLE	3,621,996	3,621,996
Tang Capital Management LLC	[2025-06-30]	OTR	0	3,200,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,968,861
VR Adviser LLC	[2025-06-30]	SOLE	2,685,448	2,685,448
Braidwell LP	[2025-06-30]	SOLE	2,578,404	2,578,404
Capital International Investors	[2025-06-30]	DFND	2,392,541	2,392,541
Driehaus Capital Management LLC	[2025-06-30]	SOLE	1,783,088	2,085,590
Commodore Capital LP	[2025-06-30]	SOLE	1,988,084	1,988,084
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	1,870,445	1,870,445
State Street Corp	[2025-06-30]	DFND	1,524,086	1,595,291
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,529,445	1,529,445
Wellington Management Group LLP	[2025-06-30]	DFND	0	1,513,478
Jefferies Financial Group Inc.	[2025-06-30]	DFND	1,388,854	1,388,854
Geode Capital Management LLC	[2025-06-30]	DFND	1,227,232	1,227,232
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	986,167	1,079,443
Franklin Resources Inc	[2025-06-30]	DFND	795,275	795,275
Polar Capital Holdings Plc	[2025-06-30]	DFND	745,000	745,000
Morgan Stanley	[2025-06-30]	DFND	660,716	671,044
Baker Bros Advisors LP	[2025-06-30]	SOLE	626,703	626,703
Deerfield Management Company LP	[2025-06-30]	DFND	613,665	613,665
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	610,200	610,200
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	606,678	606,678
Emerald Advisers LLC	[2025-06-30]	SOLE	430,675	565,863
Goldman Sachs Group Inc	[2025-06-30]	DFND	523,281	523,416
Blackstone Inc.	[2025-06-30]	OTR	0	489,248
Woodline Partners LP	[2025-06-30]	SOLE	465,152	465,152
UBS Group AG	[2025-06-30]	DFND	462,863	462,863
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