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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2023-03-31]	SOLE	0.0	7,236,454.0
Boxer Capital, LLC	[2023-03-31]	OTR	6,448,359.0	6,448,359.0
Canaan Partners XI LLC	[2023-03-31]	SOLE	4,409,991.0	4,409,991.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	3,239,595.0
FMR LLC	[2023-03-31]	DFND	3,147,781.0	3,147,987.0
Nextech Invest Ltd	[2023-03-31]	SOLE	2,518,582.0	2,518,582.0
TCG Crossover Management LLC	[2023-03-31]	SOLE	1,989,103.0	1,989,103.0
Frazier Life Sciences Management LP	[2023-03-31]	SOLE	1,421,310.0	1,421,310.0
Fairmount Funds Management LLC	[2023-03-31]	SOLE	1,416,998.0	1,416,998.0
BlackRock Inc.	[2023-03-31]	SOLE	648,316.0	666,885.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	628,453.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	494,403.0	494,403.0
Woodline Partners LP	[2023-03-31]	SOLE	410,435.0	410,435.0
Geode Capital Management LLC	[2023-03-31]	DFND	286,104.0	286,104.0
State Street Corp	[2023-03-31]	DFND	217,389.0	232,089.0
JPMorgan Chase & Co	[2023-03-31]	DFND	167,716.0	192,509.0
Driehaus Capital Management LLC	[2023-03-31]	SOLE	134,173.0	134,173.0
Northern Trust Corp	[2023-03-31]	DFND	575.0	107,542.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	102,370.0	102,370.0
Logos Global Management LP	[2023-03-31]	SOLE	87,673.0	87,673.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	84,260.0
Bank of America Corp /DE/	[2023-03-31]	DFND	1,910.0	58,011.0
Ikarian Capital LLC	[2023-03-31]	SOLE	48,170.0	48,170.0
Artia Global Partners LP	[2023-03-31]	SOLE	45,253.0	45,253.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	35,917.0	41,531.0
Victory Capital Management Inc	[2023-03-31]	SOLE	33,760.0	33,760.0
Fishman Jay A Ltd/Mi	[2023-03-31]	SOLE	0.0	22,000.0
RhumbLine Advisers	[2023-03-31]	SOLE	8,952.0	21,926.0
Mariner LLC	[2023-03-31]	SOLE	180.0	21,529.0
LPL Financial LLC	[2023-03-31]	SOLE	0.0	19,500.0
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