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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BVF Inc/IL	[2023-03-31]	DFND	0.0	3,614,662.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,559,823.0	1,559,823.0
Rubric Capital Management LP	[2023-03-31]	SOLE	1,487,385.0	1,487,385.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,141,226.0
Laurion Capital Management LP	[2023-03-31]	SOLE	698,000.0	698,000.0
Samsara Biocapital LLC	[2023-03-31]	SOLE	689,709.0	689,709.0
BlackRock Inc.	[2023-03-31]	SOLE	447,682.0	447,801.0
MAI Capital Management	[2023-03-31]	SOLE	307,552.0	379,468.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	300,000.0	300,000.0
Aisling Capital Management LP	[2023-03-31]	SOLE	288,571.0	288,571.0
Geode Capital Management LLC	[2023-03-31]	DFND	224,438.0	224,438.0
Gilder Gagnon Howe & Co LLC	[2023-03-31]	DFND	0.0	160,515.0
Millennium Management LLC	[2023-03-31]	SOLE	145,347.0	145,347.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	100,599.0	125,299.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	125,000.0	125,000.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	93,767.0	102,937.0
Acadian Asset Management LLC	[2023-03-31]	DFND	96,135.0	96,135.0
Jasper Ridge Partners LP	[2023-03-31]	SOLE	92,939.0	92,939.0
State Street Corp	[2023-03-31]	DFND	65,867.0	65,867.0
Ensign Peak Advisors, Inc	[2023-03-31]	SOLE	63,406.0	63,406.0
Morgan Stanley	[2023-03-31]	DFND	1,585.0	55,886.0
Jane Street Group LLC	[2023-03-31]	DFND	55,465.0	55,465.0
Northern Trust Corp	[2023-03-31]	DFND	0.0	38,709.0
Hamilton Lane Advisors LLC	[2023-03-31]	SOLE	0.0	35,791.0
Trust Co of Toledo NA /OH/	[2023-03-31]	SOLE	28,000.0	28,000.0
Bank of America Corp /DE/	[2023-03-31]	DFND	0.0	23,241.0
Dimensional Fund Advisors LP	[2023-03-31]	DFND	0.0	21,494.0
Bailard Inc	[2023-03-31]	SOLE	19,900.0	19,900.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	12,724.0	15,719.0
Two Sigma Investments LP	[2023-03-31]	SOLE	14,549.0	14,549.0
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