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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RA Capital Management LP	[2025-06-30]	SOLE	39,646,039	39,646,039
5AM Venture Management LLC	[2025-06-30]	SOLE	6,361,723	6,361,723
Susquehanna International Group LLP	[2025-06-30]	OTR	0	2,860,700
FMR LLC	[2025-06-30]	DFND	2,086,202	2,092,686
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,905,243
UBS Group AG	[2025-06-30]	DFND	1,531,636	1,531,636
Jane Street Group LLC	[2025-06-30]	DFND	569,413	1,159,613
Johnson & Johnson	[2025-06-30]	DFND	0	1,074,658
Citadel Advisors LLC	[2025-06-30]	DFND	756,900	756,900
Sarissa Capital Management LP	[2025-06-30]	SOLE	508,016	508,016
HRT Financial LP	[2025-06-30]	DFND	474,575	474,575
Renaissance Technologies LLC	[2025-06-30]	SOLE	468,112	468,112
Geode Capital Management LLC	[2025-06-30]	DFND	435,560	435,560
Scientech Research LLC	[2025-06-30]	SOLE	403,859	403,859
BlackRock, Inc.	[2025-06-30]	SOLE	374,763	374,763
Virtu Financial LLC	[2025-06-30]	DFND	275,912	275,912
Goldman Sachs Group Inc	[2025-06-30]	DFND	180,788	180,788
Two Sigma Investments LP	[2025-06-30]	SOLE	169,636	169,636
State Street Corp	[2025-06-30]	DFND	115,934	115,934
Millennium Management LLC	[2025-06-30]	SOLE	0	110,000
Eisler Capital Management Ltd.	[2025-06-30]	DFND	100,500	100,500
Two Sigma Securities LLC	[2025-06-30]	SOLE	94,394	94,394
Trustees of Columbia University in the City of New York	[2025-06-30]	SOLE	91,910	91,910
Citigroup Inc	[2025-06-30]	DFND	87,485	87,485
Northern Trust Corp	[2025-06-30]	DFND	72,417	72,417
Bollard Group LLC	[2025-06-30]	DFND	0	55,555
LMR Partners LLP	[2025-06-30]	SOLE	50,000	50,000
XTX Topco Ltd	[2025-06-30]	DFND	40,943	40,943
Chicago Partners Investment Group LLC	[2025-06-30]	SOLE	0	10,887
Vanguard Group Inc	[2025-06-30]	DFND	0	10,363
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