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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RTW Investments LP	[2025-06-30]	SOLE	4,251,616	4,251,616
Balyasny Asset Management LP	[2025-06-30]	SOLE	4,205,968	4,205,968
BVF Inc/IL	[2025-06-30]	DFND	0	3,404,425
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,349,335
Nantahala Capital Management LLC	[2025-06-30]	SOLE	2,954,735	2,954,735
BlackRock, Inc.	[2025-06-30]	SOLE	2,689,945	2,758,914
J Goldman & Co LP	[2025-06-30]	SOLE	2,454,519	2,454,519
State Street Corp	[2025-06-30]	DFND	2,191,394	2,251,424
Armistice Capital LLC	[2025-06-30]	SOLE	2,136,000	2,136,000
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	2,043,563	2,043,563
Vivo Capital LLC	[2025-06-30]	SOLE	1,538,461	1,538,461
AIGH Capital Management LLC	[2025-06-30]	SOLE	1,496,131	1,496,131
Stonepine Capital Management LLC	[2025-06-30]	SOLE	1,460,386	1,460,386
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,450,575	1,450,680
Foresite Capital Management VI LLC	[2025-06-30]	SOLE	1,276,520	1,276,520
Geode Capital Management LLC	[2025-06-30]	DFND	1,199,259	1,199,259
Morgan Stanley	[2025-06-30]	DFND	1,096,165	1,119,756
Polar Capital Holdings Plc	[2025-06-30]	DFND	1,000,000	1,000,000
Logos Global Management LP	[2025-06-30]	SOLE	1,000,000	1,000,000
Soleus Capital Management LP	[2025-06-30]	SOLE	935,909	935,909
Acorn Capital Advisors LLC	[2025-06-30]	SOLE	779,498	779,498
Nomura Holdings Inc	[2025-06-30]	DFND	674,596	674,596
Exome Asset Management LLC	[2025-06-30]	SOLE	599,900	599,900
Two Sigma Investments LP	[2025-06-30]	SOLE	587,021	587,021
AIGH Capital Management LLC	[2025-06-30]	OTR	0	507,048
UBS Group AG	[2025-06-30]	DFND	400,675	401,250
Jefferies Financial Group Inc.	[2025-06-30]	DFND	397,755	397,755
Royal Bank of Canada	[2025-06-30]	DFND	391,053	392,716
Nuveen, LLC	[2025-06-30]	DFND	379,581	379,581
Squarepoint Ops LLC	[2025-06-30]	DFND	0	351,569
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