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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Cormorant Asset Management LP	[2025-06-30]	DFND	1,370,938	1,370,938
Citadel Advisors LLC	[2025-06-30]	DFND	1,040,070	1,040,070
Acorn Capital Advisors LLC	[2025-06-30]	SOLE	736,572	736,572
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	644,134	644,134
DAFNA Capital Management LLC	[2025-06-30]	SOLE	636,103	636,103
Kennedy Capital Management LLC	[2025-06-30]	SOLE	570,740	570,740
Vanguard Group Inc	[2025-06-30]	SOLE	0	495,293
Palo Alto Investors LP	[2025-06-30]	SOLE	445,434	445,434
Patient Square Capital LP	[2025-06-30]	SOLE	317,033	317,033
Ikarian Capital LLC	[2025-06-30]	SOLE	290,000	290,000
Exome Asset Management LLC	[2025-06-30]	SOLE	208,970	208,970
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	161,951	161,951
Geode Capital Management LLC	[2025-06-30]	DFND	133,329	133,329
Jane Street Group LLC	[2025-06-30]	DFND	124,822	124,822
TFG Asset Management GP Ltd	[2025-06-30]	DFND	0	115,384
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	106,459
Squarepoint Ops LLC	[2025-06-30]	DFND	0	78,474
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	76,958	76,958
Prelude Capital Management LLC	[2025-06-30]	OTR	0	64,584
Susquehanna International Group LLP	[2025-06-30]	OTR	57,814	57,814
XTX Topco Ltd	[2025-06-30]	DFND	56,908	56,908
Staley Capital Advisers Inc	[2025-06-30]	SOLE	51,472	51,472
Harvest Investment Services LLC	[2025-06-30]	SOLE	0	51,326
BlackRock, Inc.	[2025-06-30]	SOLE	44,405	44,405
HRT Financial LP	[2025-06-30]	DFND	42,037	42,037
Velan Capital Investment Management LP	[2025-06-30]	SOLE	30,000	30,000
Northern Trust Corp	[2025-06-30]	DFND	23,110	23,110
Acadian Asset Management LLC	[2025-06-30]	DFND	22,418	22,418
Raymond James Financial Inc	[2025-06-30]	DFND	0	22,164
Commonwealth Equity Services LLC	[2025-06-30]	SOLE	0	18,298
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