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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Woodline Partners LP	[2025-06-30]	SOLE	4,615,676	4,615,676
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	4,168,000	4,168,000
BlackRock, Inc.	[2025-06-30]	SOLE	4,001,236	4,081,544
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,879,963
FMR LLC	[2025-06-30]	DFND	2,277,374	2,289,243
Rubric Capital Management LP	[2025-06-30]	SOLE	1,958,318	1,958,318
Nantahala Capital Management LLC	[2025-06-30]	SOLE	1,471,936	1,471,936
Geode Capital Management LLC	[2025-06-30]	DFND	1,242,386	1,242,386
State Street Corp	[2025-06-30]	DFND	1,169,431	1,241,658
683 Capital Management LLC	[2025-06-30]	DFND	1,125,000	1,125,000
Legal & General Group Plc	[2025-06-30]	DFND	935,677	935,677
Susquehanna International Group LLP	[2025-06-30]	OTR	161,493	783,093
Stonepine Capital Management LLC	[2025-06-30]	SOLE	775,620	775,620
Velan Capital Investment Management LP	[2025-06-30]	SOLE	715,000	715,000
AIGH Capital Management LLC	[2025-06-30]	SOLE	683,244	683,244
Millennium Management LLC	[2025-06-30]	SOLE	634,820	634,820
Retirement Planning Co of New England, Inc.	[2025-06-30]	SOLE	0	553,297
Kingdon Capital Management LLC	[2025-06-30]	DFND	450,000	450,000
Northern Trust Corp	[2025-06-30]	DFND	416,891	416,891
Goldman Sachs Group Inc	[2025-06-30]	DFND	374,552	374,792
Mystic Asset Management Inc	[2025-06-30]	SOLE	0	346,652
Schroder Investment Management Group	[2025-06-30]	SOLE	315,469	315,469
Jane Street Group LLC	[2025-06-30]	DFND	183,104	298,604
Janney Montgomery Scott LLC	[2025-06-30]	SOLE	256,664	256,664
AIGH Capital Management LLC	[2025-06-30]	OTR	0	235,649
Propel Bio Management LLC	[2025-06-30]	DFND	84,874	231,874
Bank of America Corp /DE/	[2025-06-30]	DFND	8,988	223,852
Stratos Wealth Partners Ltd	[2025-06-30]	SOLE	0	220,000
Morgan Stanley	[2025-06-30]	DFND	209,132	213,088
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	189,313	189,313
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