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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Propel Bio Management LLC	[2025-06-30]	DFND	3,601,913	6,153,091
Franklin Resources Inc	[2025-06-30]	DFND	4,459,014	4,459,014
Alyeska Investment Group LP	[2025-06-30]	SOLE	3,504,333	3,504,333
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,135,069
Clearline Capital LP	[2025-06-30]	SOLE	1,326,259	1,326,259
Simplify Asset Management Inc	[2025-06-30]	SOLE	1,184,512	1,184,512
Hudson Bay Capital Management LP	[2025-06-30]	SOLE	1,173,532	1,173,532
Heights Capital Management Inc	[2025-06-30]	OTR	989,509	989,509
Nantahala Capital Management LLC	[2025-06-30]	SOLE	898,885	898,885
Millennium Management LLC	[2025-06-30]	SOLE	386,200	386,200
Geode Capital Management LLC	[2025-06-30]	DFND	362,200	362,200
Stonepine Capital Management LLC	[2025-06-30]	SOLE	333,333	333,333
BlackRock, Inc.	[2025-06-30]	SOLE	314,699	314,699
Raymond James Financial Inc	[2025-06-30]	DFND	0	295,058
Shay Capital LLC	[2025-06-30]	SOLE	292,647	292,647
LPL Financial LLC	[2025-06-30]	SOLE	0	255,833
Long Focus Capital Management LLC	[2025-06-30]	SOLE	248,099	248,099
Northern Trust Corp	[2025-06-30]	DFND	215,845	215,845
Caption Management LLC	[2025-06-30]	SOLE	200,000	200,000
State Street Corp	[2025-06-30]	DFND	157,884	157,884
Highbridge Capital Management LLC	[2025-06-30]	SOLE	0	132,937
Royal Bank of Canada	[2025-06-30]	DFND	117,934	117,934
Y-Intercept (Hong Kong) Ltd	[2025-06-30]	SOLE	116,409	116,409
Morgan Stanley	[2025-06-30]	DFND	103,384	106,297
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	102,581	102,581
Alpine Global Management, LLC	[2025-06-30]	SOLE	100,000	100,000
UBS Group AG	[2025-06-30]	DFND	84,914	84,914
Susquehanna International Group LLP	[2025-06-30]	OTR	72,715	83,315
Jane Street Group LLC	[2025-06-30]	DFND	70,452	70,452
Brevan Howard Capital Management LP	[2025-06-30]	DFND	64,348	64,348
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