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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BVF Inc/IL	[2025-06-30]	DFND	0	1,028,049
Nantahala Capital Management LLC	[2025-06-30]	SOLE	995,000	995,000
OrbiMed Advisors LLC	[2025-06-30]	SOLE	967,000	967,000
RA Capital Management LP	[2025-06-30]	SOLE	932,973	932,973
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	607,872	607,872
Deep Track Capital LP	[2025-06-30]	SOLE	567,103	567,103
TCG Crossover Management LLC	[2025-06-30]	SOLE	483,000	483,000
Commodore Capital LP	[2025-06-30]	SOLE	483,000	483,000
Bank of America Corp /DE/	[2025-06-30]	DFND	0	406,571
RWA Wealth Partners LLC	[2025-06-30]	SOLE	261,016	261,016
Vanguard Group Inc	[2025-06-30]	SOLE	0	165,801
BlackRock, Inc.	[2025-06-30]	SOLE	155,899	155,899
Velan Capital Investment Management LP	[2025-06-30]	SOLE	154,972	154,972
Perceptive Advisors LLC	[2025-06-30]	SOLE	139,667	139,667
Geode Capital Management LLC	[2025-06-30]	DFND	110,460	110,460
Adar1 Capital Management LLC	[2025-06-30]	SOLE	104,730	104,730
UBS Group AG	[2025-06-30]	DFND	83,723	83,724
SIO Capital Management LLC	[2025-06-30]	SOLE	72,173	72,173
Ikarian Capital LLC	[2025-06-30]	SOLE	35,300	35,300
Northern Trust Corp	[2025-06-30]	DFND	22,673	22,673
Walleye Capital LLC	[2025-06-30]	SOLE	20,613	20,613
Two Sigma Investments LP	[2025-06-30]	SOLE	12,889	12,889
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	11,321
Quadrature Capital Ltd	[2025-06-30]	OTR	0	10,976
Allostery Investments LP	[2025-06-30]	SOLE	9,000	9,000
Vanguard Group Inc	[2025-06-30]	DFND	0	1,140
JPMorgan Chase & Co	[2025-06-30]	DFND	74	74
SBI Securities Co., Ltd.	[2025-06-30]	DFND	22	22
Morgan Stanley	[2025-06-30]	DFND	3	10
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	5
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