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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
First Light Asset Management LLC	[2025-06-30]	SOLE	4,529,243	4,529,243
BlackRock, Inc.	[2025-06-30]	SOLE	3,428,848	3,500,290
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,630,465
Morgan Stanley	[2025-06-30]	DFND	2,438,333	2,510,703
Balyasny Asset Management LP	[2025-06-30]	SOLE	1,931,158	1,931,158
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	1,625,908	1,625,908
Soleus Capital Management LP	[2025-06-30]	SOLE	1,459,395	1,459,395
Wasatch Advisors LP	[2025-06-30]	SOLE	1,355,573	1,433,782
State Street Corp	[2025-06-30]	DFND	1,055,038	1,122,731
Armistice Capital LLC	[2025-06-30]	SOLE	1,111,319	1,111,319
Geode Capital Management LLC	[2025-06-30]	DFND	1,060,599	1,060,599
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	1,023,122	1,023,122
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	704,414	748,475
DAFNA Capital Management LLC	[2025-06-30]	SOLE	741,782	741,782
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	728,741	728,741
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	674,551	674,551
Marshall Wace LLP	[2025-06-30]	OTR	0	641,434
Deutsche Bank AG	[2025-06-30]	DFND	836	585,629
Silvercrest Asset Management Group LLC	[2025-06-30]	SOLE	328,408	580,233
Tocqueville Asset Management LP	[2025-06-30]	SOLE	484,900	484,900
Squarepoint Ops LLC	[2025-06-30]	DFND	0	483,563
Bank of America Corp /DE/	[2025-06-30]	DFND	6,098	453,676
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	448,433	448,433
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	403,827	403,827
Northern Trust Corp	[2025-06-30]	DFND	388,044	388,453
JPMorgan Chase & Co	[2025-06-30]	DFND	336,165	379,070
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	378,170	378,170
Oberweis Asset Management Inc	[2025-06-30]	SOLE	328,100	328,100
ProSight Management LP	[2025-06-30]	SOLE	282,809	282,809
FMR LLC	[2025-06-30]	DFND	263,805	268,873
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