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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Wasatch Advisors LP	[2025-06-30]	SOLE	6,702,951	7,424,662
Lynx1 Capital Management LP	[2025-06-30]	OTR	0	7,098,133
Soleus Capital Management LP	[2025-06-30]	SOLE	6,978,942	6,978,942
OrbiMed Advisors LLC	[2025-06-30]	DFND	2,174,700	6,830,300
Morgan Stanley	[2025-06-30]	DFND	4,753,226	4,754,188
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,999,888
Bank of America Corp /DE/	[2025-06-30]	DFND	0	2,008,004
BlackRock, Inc.	[2025-06-30]	SOLE	1,821,197	1,828,614
Bain Capital Life Sciences Investors, LLC	[2025-06-30]	SOLE	1,111,910	1,111,910
Millennium Management LLC	[2025-06-30]	SOLE	1,101,342	1,101,342
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,093,188	1,093,188
Tang Capital Management LLC	[2025-06-30]	OTR	0	900,000
Goldman Sachs Group Inc	[2025-06-30]	DFND	880,258	880,258
Two Sigma Advisers LP	[2025-06-30]	SOLE	775,200	811,400
Geode Capital Management LLC	[2025-06-30]	DFND	745,053	745,053
Two Sigma Investments LP	[2025-06-30]	SOLE	683,599	683,599
UBS Group AG	[2025-06-30]	DFND	503,591	572,026
Jane Street Group LLC	[2025-06-30]	DFND	492,612	492,612
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	441,735	441,735
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	371,431	410,309
AQR Capital Management LLC	[2025-06-30]	DFND	381,329	381,339
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	331,897	331,897
State Street Corp	[2025-06-30]	DFND	287,373	287,373
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	239,959
Royal Bank of Canada	[2025-06-30]	DFND	238,868	238,868
Hennion & Walsh Asset Management Inc	[2025-06-30]	SOLE	208,766	208,766
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	206,177
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	204,505	204,505
FMR LLC	[2025-06-30]	DFND	185,681	201,358
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	200,000	200,000
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