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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	3,300,389	3,300,389
BlackRock, Inc.	[2025-06-30]	SOLE	1,682,448	1,717,197
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,570,759
Citadel Advisors LLC	[2025-06-30]	DFND	867,908	867,908
Deerfield Management Company LP	[2025-06-30]	DFND	812,561	812,561
Geode Capital Management LLC	[2025-06-30]	DFND	703,171	703,171
Vivo Capital LLC	[2025-06-30]	SOLE	569,526	569,526
Marshall Wace LLP	[2025-06-30]	OTR	0	483,259
State Street Corp	[2025-06-30]	DFND	432,142	473,893
Morgan Stanley	[2025-06-30]	DFND	342,672	457,440
Oberweis Asset Management Inc	[2025-06-30]	SOLE	419,400	419,400
Invesco Ltd.	[2025-06-30]	DFND	0	346,978
Ikarian Capital LLC	[2025-06-30]	SOLE	322,390	322,390
Kennedy Capital Management LLC	[2025-06-30]	SOLE	319,047	319,047
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	306,300
Palisades Investment Partners LLC	[2025-06-30]	SOLE	219,357	270,310
Northern Trust Corp	[2025-06-30]	DFND	267,700	267,700
Millennium Management LLC	[2025-06-30]	SOLE	249,755	249,755
Propel Bio Management LLC	[2025-06-30]	DFND	119,423	226,052
Jane Street Group LLC	[2025-06-30]	DFND	206,783	225,183
Informed Momentum Co LLC	[2025-06-30]	SOLE	86,160	212,964
APIS Capital Advisors LLC	[2025-06-30]	SOLE	205,000	205,000
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	203,191	203,191
Tudor Investment Corp ET AL	[2025-06-30]	DFND	197,749	197,749
Jump Financial, LLC	[2025-06-30]	DFND	197,466	197,466
Renaissance Technologies LLC	[2025-06-30]	SOLE	178,000	178,000
Private Wealth Advisors LLC	[2025-06-30]	SOLE	0	168,596
JPMorgan Chase & Co	[2025-06-30]	DFND	153,892	168,127
Goldman Sachs Group Inc	[2025-06-30]	DFND	153,534	153,554
Adar1 Capital Management LLC	[2025-06-30]	SOLE	149,385	149,385
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