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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Tang Capital Management LLC	[2025-06-30]	OTR	0	4,997,399
Nantahala Capital Management LLC	[2025-06-30]	SOLE	4,297,926	4,297,926
BlackRock, Inc.	[2025-06-30]	SOLE	4,074,947	4,184,056
Caligan Partners LP	[2025-06-30]	SOLE	3,341,970	3,341,970
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,207,174
Perceptive Advisors LLC	[2025-06-30]	SOLE	2,474,843	2,474,843
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	2,435,550	2,435,550
Soleus Capital Management LP	[2025-06-30]	SOLE	2,119,000	2,119,000
Millennium Management LLC	[2025-06-30]	SOLE	1,483,426	1,665,326
Frontier Capital Management Co LLC	[2025-06-30]	SOLE	680,767	1,664,828
State Street Corp	[2025-06-30]	DFND	1,281,700	1,406,594
TRI Locum Partners LP	[2025-06-30]	SOLE	1,239,031	1,239,031
Geode Capital Management LLC	[2025-06-30]	DFND	1,231,841	1,231,841
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	1,171,093
Eversept Partners LP	[2025-06-30]	SOLE	1,170,311	1,170,311
UBS Group AG	[2025-06-30]	DFND	1,072,979	1,076,584
Schroder Investment Management Group	[2025-06-30]	SOLE	1,056,773	1,056,773
Rice Hall James & Associates LLC	[2025-06-30]	SOLE	812,561	996,040
Morgan Stanley	[2025-06-30]	DFND	933,618	961,153
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	956,602	957,741
Stonepine Capital Management LLC	[2025-06-30]	SOLE	916,500	916,500
Nuveen, LLC	[2025-06-30]	DFND	894,771	896,472
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	726,198	726,198
Great Point Partners LLC	[2025-06-30]	SOLE	0	720,118
JPMorgan Chase & Co	[2025-06-30]	DFND	609,851	692,486
Pinnacle Associates Ltd	[2025-06-30]	SOLE	685,960	685,960
Oberweis Asset Management Inc	[2025-06-30]	SOLE	677,600	677,600
Citadel Advisors LLC	[2025-06-30]	DFND	640,859	640,859
Zimmer Partners LP	[2025-06-30]	SOLE	630,000	630,000
AWH Capital LP	[2025-06-30]	SOLE	625,000	625,000
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