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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
First Manhattan Co LLC	[2023-03-31]	SOLE	4,016,138.0	4,016,138.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	3,569,000.0	3,569,000.0
Tang Capital Management LLC	[2023-03-31]	OTR	0.0	3,197,399.0
Millennium Management LLC	[2023-03-31]	SOLE	2,476,495.0	2,476,495.0
BlackRock Inc.	[2023-03-31]	SOLE	2,392,050.0	2,440,969.0
Great Point Partners LLC	[2023-03-31]	DFND	0.0	2,192,816.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	1,814,376.0
Schroder Investment Management Group	[2023-03-31]	SOLE	1,641,071.0	1,641,071.0
AWH Capital LP	[2023-03-31]	SOLE	1,563,000.0	1,563,000.0
Caligan Partners LP	[2023-03-31]	SOLE	1,523,484.0	1,523,484.0
Boothbay Fund Management LLC	[2023-03-31]	OTR	0.0	1,106,449.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	803,458.0	803,458.0
State Street Corp	[2023-03-31]	DFND	695,319.0	750,365.0
Geode Capital Management LLC	[2023-03-31]	DFND	712,876.0	712,876.0
Stonepine Capital Management LLC	[2023-03-31]	SOLE	578,795.0	578,795.0
Jefferies Financial Group Inc.	[2023-03-31]	DFND	500,000.0	500,000.0
ExodusPoint Capital Management LP	[2023-03-31]	SOLE	470,048.0	470,048.0
Northern Trust Corp	[2023-03-31]	DFND	21,668.0	326,872.0
Brandywine Global Investment Management LLC	[2023-03-31]	SOLE	311,800.0	311,800.0
Monashee Investment Management LLC	[2023-03-31]	SOLE	285,000.0	285,000.0
Essex Investment Management Co LLC	[2023-03-31]	SOLE	141,840.0	246,647.0
FourWorld Capital Management LLC	[2023-03-31]	SOLE	245,590.0	245,590.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	28,190.0	226,429.0
Eversept Partners LP	[2023-03-31]	SOLE	221,551.0	221,551.0
Citadel Advisors LLC	[2023-03-31]	DFND	206,221.0	206,221.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	181,369.0	182,403.0
Potomac Capital Management Inc	[2023-03-31]	SOLE	166,100.0	166,100.0
Rice Hall James & Associates LLC	[2023-03-31]	SOLE	147,647.0	160,594.0
TRI Locum Partners LP	[2023-03-31]	SOLE	160,269.0	160,269.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	135,974.0	135,999.0
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