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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Bellevue Group AG	[2025-06-30]	DFND	9,919,992	9,919,992
Armistice Capital LLC	[2025-06-30]	SOLE	5,960,000	5,960,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,104,830
Wasatch Advisors LP	[2025-06-30]	SOLE	3,251,022	3,251,022
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	3,175,665	3,175,665
Millennium Management LLC	[2025-06-30]	SOLE	2,015,864	2,015,864
BlackRock, Inc.	[2025-06-30]	SOLE	1,811,862	1,817,529
EcoR1 Capital LLC	[2025-06-30]	SOLE	1,602,717	1,602,717
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,326,494	1,326,494
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	951,740	1,004,798
Two Sigma Advisers LP	[2025-06-30]	SOLE	822,300	857,100
Jane Street Group LLC	[2025-06-30]	DFND	758,204	758,204
Goldman Sachs Group Inc	[2025-06-30]	DFND	698,288	698,288
Geode Capital Management LLC	[2025-06-30]	DFND	683,538	683,538
Connor Clark & Lunn Investment Management Ltd	[2025-06-30]	SOLE	682,277	682,277
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	398,515	465,868
JPMorgan Chase & Co	[2025-06-30]	DFND	460,137	460,137
Morgan Stanley	[2025-06-30]	DFND	434,934	446,222
Macquarie Group Ltd	[2025-06-30]	SOLE	420,000	420,000
Two Sigma Investments LP	[2025-06-30]	SOLE	407,288	407,288
Marshall Wace LLP	[2025-06-30]	OTR	0	405,911
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	352,105
Pinnacle Associates Ltd	[2025-06-30]	SOLE	350,967	350,967
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	334,349	334,349
State Street Corp	[2025-06-30]	DFND	300,287	300,287
Vestal Point Capital LP	[2025-06-30]	SOLE	280,000	280,000
Susquehanna International Group LLP	[2025-06-30]	OTR	196,625	238,125
Citadel Advisors LLC	[2025-06-30]	DFND	221,278	221,278
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AME	[2025-06-30]	DFND	219,000	219,000
Tang Capital Management LLC	[2025-06-30]	OTR	0	218,856
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