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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,284,966	1,284,966
Kingdon Capital Management LLC	[2025-06-30]	DFND	859,261	859,261
Vanguard Group Inc	[2025-06-30]	SOLE	0	695,615
Nantahala Capital Management LLC	[2025-06-30]	SOLE	594,661	594,661
Westside Investment Management, Inc.	[2025-06-30]	SOLE	0	279,525
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AM	[2025-06-30]	DFND	241,161	241,161
Universal- Beteiligungs- und Servicegesellschaft mbH	[2025-06-30]	DFND	200,000	200,000
Geode Capital Management LLC	[2025-06-30]	DFND	199,509	199,509
JPMorgan Chase & Co	[2025-06-30]	DFND	182,300	182,300
Morgan Stanley	[2025-06-30]	DFND	17,783	75,337
Regions Financial Corp	[2025-06-30]	DFND	68,500	68,500
Northern Trust Corp	[2025-06-30]	DFND	60,608	60,608
BlackRock, Inc.	[2025-06-30]	SOLE	57,404	57,404
State Street Corp	[2025-06-30]	DFND	40,800	40,800
Fermata Advisors LLC	[2025-06-30]	SOLE	40,049	40,049
Citadel Advisors LLC	[2025-06-30]	DFND	29,098	29,098
Susquehanna International Group LLP	[2025-06-30]	OTR	0	29,000
Laird Norton Wetherby Trust Company, LLC	[2025-06-30]	SOLE	25,000	25,000
Hohimer Wealth Management LLC	[2025-06-30]	SOLE	0	20,000
XTX Topco Ltd	[2025-06-30]	DFND	17,627	17,627
Tamar Securities LLC	[2025-06-30]	SOLE	0	13,990
Creative Planning	[2025-06-30]	SOLE	0	13,500
Renaissance Technologies LLC	[2025-06-30]	SOLE	13,500	13,500
Jane Street Group LLC	[2025-06-30]	DFND	12,833	12,833
Wolverine Trading LLC	[2025-06-30]	DFND	0	11,254
Cambridge Investment Research Advisors Inc	[2025-06-30]	SOLE	0	10,001
Dimensional Fund Advisors LP	[2025-06-30]	DFND	0	9,065
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	7,054	7,054
UBS Group AG	[2025-06-30]	DFND	6,060	6,060
Vanguard Group Inc	[2025-06-30]	DFND	0	2,724
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