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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
ARK Investment Management LLC	[2023-03-31]	SOLE	26,141,127.0	27,753,679.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	21,861,722.0
BlackRock Inc.	[2023-03-31]	SOLE	19,582,630.0	20,200,979.0
Madrone Advisors, LLC	[2023-03-31]	SOLE	16,415,933.0	16,415,933.0
Nikko Asset Management Americas Inc	[2023-03-31]	SOLE	12,948,112.0	14,006,515.0
Sumitomo Mitsui Trust Holdings, Inc.	[2023-03-31]	DFND	14,006,515.0	14,006,515.0
Jackson Square Partners LLC	[2023-03-31]	SOLE	10,053,317.0	12,097,961.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	7,289,368.0
Bellevue Group AG	[2023-03-31]	DFND	7,026,106.0	7,026,106.0
Farallon Capital Management LLC	[2023-03-31]	OTR	6,355,120.0	6,355,120.0
Citadel Advisors LLC	[2023-03-31]	DFND	5,660,372.0	5,660,372.0
T. Rowe Price Investment Management, Inc.	[2023-03-31]	SOLE	1,633,604.0	5,420,563.0
State Street Corp	[2023-03-31]	DFND	4,824,688.0	5,362,819.0
Geode Capital Management LLC	[2023-03-31]	DFND	4,731,109.0	4,731,109.0
FMR LLC	[2023-03-31]	DFND	4,356,298.0	4,368,167.0
Capital International Investors	[2023-03-31]	DFND	4,215,801.0	4,215,801.0
Macquarie Group Ltd	[2023-03-31]	SOLE	3,957,007.0	4,013,617.0
Avidity Partners Management LP	[2023-03-31]	SOLE	3,812,600.0	3,812,600.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	643,905.0	3,526,494.0
Deep Track Capital LP	[2023-03-31]	SOLE	3,504,390.0	3,504,390.0
Capital World Investors	[2023-03-31]	DFND	3,390,000.0	3,390,000.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	3,175,432.0	3,345,887.0
Lord Abbett & Co LLC	[2023-03-31]	SOLE	2,979,167.0	3,275,407.0
Northern Trust Corp	[2023-03-31]	DFND	151,516.0	2,530,559.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	2,186,942.0	2,319,292.0
Iron Triangle Partners LP	[2023-03-31]	SOLE	2,300,000.0	2,300,000.0
SEI Investments Co	[2023-03-31]	SOLE	2,156,166.0	2,156,166.0
Morgan Stanley	[2023-03-31]	DFND	1,734,718.0	2,054,528.0
Oracle Investment Management Inc	[2023-03-31]	SOLE	2,015,495.0	2,015,495.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	1,740,409.0	1,740,409.0
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