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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	7,901,218	7,901,218
BlackRock, Inc.	[2025-06-30]	SOLE	3,807,782	3,939,398
Adar1 Capital Management LLC	[2025-06-30]	SOLE	3,375,009	3,375,009
Armistice Capital LLC	[2025-06-30]	SOLE	2,236,000	2,236,000
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,114,993
Citadel Advisors LLC	[2025-06-30]	DFND	1,370,222	1,370,222
Palo Alto Investors LP	[2025-06-30]	SOLE	1,274,753	1,274,753
Federated Hermes Inc	[2025-06-30]	DFND	1,181,087	1,181,087
State Street Corp	[2025-06-30]	DFND	875,598	1,005,002
Susquehanna International Group LLP	[2025-06-30]	OTR	91,950	955,350
Morgan Stanley	[2025-06-30]	DFND	826,057	953,256
Geode Capital Management LLC	[2025-06-30]	DFND	933,446	933,446
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	878,630	922,875
Rangeley Capital LLC	[2025-06-30]	SOLE	715,367	715,367
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	606,429	693,154
Balyasny Asset Management LP	[2025-06-30]	SOLE	575,792	575,792
Trexquant Investment LP	[2025-06-30]	SOLE	552,826	552,826
Goldman Sachs Group Inc	[2025-06-30]	DFND	528,319	528,323
Cubist Systematic Strategies, LLC	[2025-06-30]	DFND	0	501,764
Rock Springs Capital Management LP	[2025-06-30]	SOLE	492,601	492,601
Granahan Investment Management LLC	[2025-06-30]	SOLE	417,909	461,082
Birchview Capital LP	[2025-06-30]	SOLE	451,019	451,019
Qube Research & Technologies Ltd	[2025-06-30]	SOLE	414,828	414,828
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	391,495	391,495
Mariner LLC	[2025-06-30]	SOLE	0	386,708
Northern Trust Corp	[2025-06-30]	DFND	327,625	328,088
Jane Street Group LLC	[2025-06-30]	DFND	260,453	316,653
Nordea Investment Management AB	[2025-06-30]	DFND	0	311,605
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	307,341	307,341
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	275,084	275,084
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