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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
RTW Investments LP	[2023-03-31]	SOLE	4,600,799.0	4,600,799.0
BlackRock Inc.	[2023-03-31]	SOLE	4,313,492.0	4,402,217.0
BVF Inc/IL	[2023-03-31]	DFND	0.0	3,775,900.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,169,677.0
Farallon Capital Management LLC	[2023-03-31]	OTR	2,615,014.0	2,615,014.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	2,558,000.0	2,558,000.0
Johnson & Johnson	[2023-03-31]	DFND	0.0	2,449,183.0
State Street Corp	[2023-03-31]	DFND	2,324,456.0	2,413,701.0
Cormorant Asset Management LP	[2023-03-31]	DFND	1,700,000.0	1,700,000.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,646,480.0	1,646,480.0
Morgan Stanley	[2023-03-31]	DFND	1,559,750.0	1,570,510.0
Kynam Capital Management LP	[2023-03-31]	SOLE	1,375,000.0	1,375,000.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	1,366,080.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	1,128,158.0	1,194,578.0
Millennium Management LLC	[2023-03-31]	SOLE	1,122,342.0	1,122,342.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	965,152.0	965,152.0
Deutsche Bank AG	[2023-03-31]	DFND	52,130.0	958,891.0
Geode Capital Management LLC	[2023-03-31]	DFND	925,993.0	925,993.0
683 Capital Management LLC	[2023-03-31]	DFND	873,000.0	873,000.0
Susquehanna International Group LLP	[2023-03-31]	DFND	124,084.0	868,784.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	828,471.0	828,471.0
Bank of America Corp /DE/	[2023-03-31]	DFND	14,902.0	766,990.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	690,867.0	690,867.0
Candriam SCA	[2023-03-31]	SOLE	625,000.0	625,000.0
Woodline Partners LP	[2023-03-31]	SOLE	618,615.0	618,615.0
Barclays PLC	[2023-03-31]	SOLE	583,737.0	583,737.0
Voloridge Investment Management LLC	[2023-03-31]	SOLE	465,323.0	465,323.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	459,420.0	459,450.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	377,600.0	449,800.0
Jennison Associates LLC	[2023-03-31]	DFND	428,938.0	428,938.0
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