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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock, Inc.	[2025-06-30]	SOLE	9,482,436	9,630,341
Farallon Capital Management LLC	[2025-06-30]	OTR	6,172,006	6,172,006
RTW Investments LP	[2025-06-30]	SOLE	5,756,277	5,756,277
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,234,689
Deep Track Capital LP	[2025-06-30]	SOLE	3,245,899	3,245,899
BVF Inc/IL	[2025-06-30]	DFND	0	3,211,041
State Street Corp	[2025-06-30]	DFND	3,059,580	3,207,543
UBS Group AG	[2025-06-30]	DFND	2,500,942	2,501,251
Johnson & Johnson	[2025-06-30]	DFND	0	2,449,183
Geode Capital Management LLC	[2025-06-30]	DFND	1,444,230	1,444,230
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,092,262	1,092,262
Commodore Capital LP	[2025-06-30]	SOLE	1,075,000	1,075,000
Perceptive Advisors LLC	[2025-06-30]	SOLE	1,074,448	1,074,448
Wellington Management Group LLP	[2025-06-30]	DFND	0	1,037,738
Adar1 Capital Management LLC	[2025-06-30]	SOLE	948,069	948,069
Woodline Partners LP	[2025-06-30]	SOLE	946,884	946,884
Morgan Stanley	[2025-06-30]	DFND	827,693	868,963
Bank of America Corp /DE/	[2025-06-30]	DFND	18,448	851,832
Jefferies Financial Group Inc.	[2025-06-30]	DFND	824,019	824,019
American Century Companies Inc	[2025-06-30]	DFND	737,097	813,995
Goldman Sachs Group Inc	[2025-06-30]	DFND	761,681	767,068
Driehaus Capital Management LLC	[2025-06-30]	SOLE	586,206	757,710
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	680,197	751,977
Lynx1 Capital Management LP	[2025-06-30]	OTR	0	733,014
Invesco Ltd.	[2025-06-30]	DFND	0	721,680
Northern Trust Corp	[2025-06-30]	DFND	581,230	582,998
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	575,320	575,364
FMR LLC	[2025-06-30]	DFND	534,369	538,432
Holocene Advisors LP	[2025-06-30]	SOLE	530,326	530,326
Janus Henderson Group PLC	[2025-06-30]	DFND	0	446,828
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