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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	7,988,211.0
BlackRock Inc.	[2023-03-31]	SOLE	5,035,008.0	5,282,569.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	4,908,204.0
Avoro Capital Advisors LLC	[2023-03-31]	SOLE	3,900,000.0	3,900,000.0
JPMorgan Chase & Co	[2023-03-31]	DFND	3,313,951.0	3,702,345.0
EcoR1 Capital LLC	[2023-03-31]	SOLE	2,999,453.0	2,999,453.0
Wellington Management Group LLP	[2023-03-31]	DFND	0.0	2,933,612.0
FMR LLC	[2023-03-31]	DFND	2,637,360.0	2,644,656.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	1,632,367.0	1,855,876.0
State Street Corp	[2023-03-31]	DFND	1,598,314.0	1,773,976.0
Susquehanna International Group LLP	[2023-03-31]	DFND	139,827.0	1,348,027.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,261,971.0	1,261,971.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	1,213,356.0
Casdin Capital LLC	[2023-03-31]	SOLE	1,185,000.0	1,185,000.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	1,070,234.0	1,175,734.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	224,500.0	1,123,923.0
Two Sigma Investments LP	[2023-03-31]	SOLE	1,097,143.0	1,097,143.0
Deutsche Bank AG	[2023-03-31]	DFND	899,581.0	1,000,121.0
Citadel Advisors LLC	[2023-03-31]	DFND	992,114.0	992,114.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	897,979.0	986,872.0
American Century Companies Inc	[2023-03-31]	DFND	953,204.0	953,204.0
OrbiMed Advisors LLC	[2023-03-31]	DFND	82,900.0	940,100.0
Farallon Capital Management LLC	[2023-03-31]	OTR	913,300.0	913,300.0
Morgan Stanley	[2023-03-31]	DFND	805,021.0	889,506.0
Sands Capital Management LLC	[2023-03-31]	SOLE	652,481.0	874,765.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	849,337.0	851,737.0
Federated Hermes Inc	[2023-03-31]	DFND	816,886.0	816,922.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	764,020.0	806,478.0
Westfield Capital Management Co LP	[2023-03-31]	SOLE	661,244.0	802,658.0
Boxer Capital, LLC	[2023-03-31]	OTR	775,000.0	775,000.0
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