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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Nantahala Capital Management LLC	[2025-06-30]	SOLE	5,861,588	5,861,588
Essex Woodlands Management Inc	[2025-06-30]	SOLE	4,110,709	4,110,709
SilverArc Capital Management LLC	[2025-06-30]	SOLE	2,779,795	2,779,795
Stonepine Capital Management LLC	[2025-06-30]	SOLE	2,083,762	2,083,762
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,906,974
DAFNA Capital Management LLC	[2025-06-30]	SOLE	1,441,029	1,441,029
Perkins Capital Management Inc	[2025-06-30]	SOLE	774,910	875,865
Pentwater Capital Management LP	[2025-06-30]	SOLE	815,000	815,000
Citigroup Inc	[2025-06-30]	DFND	750,000	750,000
Velan Capital Investment Management LP	[2025-06-30]	SOLE	747,410	747,410
SIO Capital Management LLC	[2025-06-30]	SOLE	636,300	636,300
BlackRock, Inc.	[2025-06-30]	SOLE	458,506	458,506
Geode Capital Management LLC	[2025-06-30]	DFND	337,945	337,945
UBS Group AG	[2025-06-30]	DFND	245,548	245,548
Paradigm Capital Management Inc/Ny	[2025-06-30]	DFND	0	200,000
Birchview Capital LP	[2025-06-30]	SOLE	155,000	155,000
UP Strategic Wealth Investment Advisors LLC	[2025-06-30]	SOLE	0	99,888
Northern Trust Corp	[2025-06-30]	DFND	94,065	94,065
Renaissance Technologies LLC	[2025-06-30]	SOLE	67,333	67,333
State Street Corp	[2025-06-30]	DFND	63,383	63,383
JPMorgan Chase & Co	[2025-06-30]	DFND	59,519	59,519
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	57,500	57,500
PNC Financial Services Group Inc	[2025-06-30]	DFND	53,612	53,612
Destiny Wealth Partners LLC	[2025-06-30]	SOLE	0	52,500
GSA Capital Partners LLP	[2025-06-30]	SOLE	51,196	51,196
Atom Investors LP	[2025-06-30]	SOLE	42,795	42,795
Commonwealth Equity Services LLC	[2025-06-30]	SOLE	0	38,441
Wealthtrust Axiom LLC	[2025-06-30]	SOLE	0	20,500
Rollins Financial Advisors LLC	[2025-06-30]	SOLE	18,656	18,656
Solstein Capital LLC	[2025-06-30]	SOLE	16,385	16,385
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