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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Essex Woodlands Management Inc	[2023-03-31]	SOLE	4,110,709.0	4,110,709.0
OrbiMed Advisors LLC	[2023-03-31]	SOLE	3,027,542.0	3,027,542.0
Opaleye Management Inc	[2023-03-31]	SOLE	2,072,813.0	2,072,813.0
AIGH Capital Management LLC	[2023-03-31]	SOLE	1,243,970.0	1,243,970.0
Next Century Growth Investors LLC	[2023-03-31]	SOLE	777,753.0	777,753.0
Velan Capital Investment Management LP	[2023-03-31]	SOLE	746,087.0	746,087.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	707,519.0
Pentwater Capital Management LP	[2023-03-31]	SOLE	490,402.0	490,402.0
AIGH Capital Management LLC	[2023-03-31]	OTR	0.0	409,649.0
Worth Venture Partners LLC	[2023-03-31]	OTR	0.0	409,649.0
Pura Vida Investments LLC	[2023-03-31]	SOLE	371,809.0	371,809.0
Kennedy Capital Management LLC	[2023-03-31]	SOLE	316,429.0	316,429.0
Nantahala Capital Management LLC	[2023-03-31]	SOLE	256,092.0	256,092.0
Schonfeld Strategic Advisors LLC	[2023-03-31]	SOLE	215,049.0	215,049.0
Perkins Capital Management Inc	[2023-03-31]	SOLE	151,500.0	166,500.0
Jacob Asset Management of New York LLC	[2023-03-31]	SOLE	150,775.0	150,775.0
Parkman Healthcare Partners LLC	[2023-03-31]	SOLE	137,372.0	137,372.0
Kamunting Street Capital Management LP	[2023-03-31]	SOLE	136,500.0	136,500.0
Millennium Management LLC	[2023-03-31]	SOLE	104,366.0	104,366.0
Geode Capital Management LLC	[2023-03-31]	DFND	93,255.0	93,255.0
Russell Investments Group, Ltd.	[2023-03-31]	DFND	45,531.0	72,698.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	16,300.0	69,700.0
Sanders Morris Harris LLC	[2023-03-31]	SOLE	0.0	69,168.0
Susquehanna International Group LLP	[2023-03-31]	DFND	68,842.0	68,842.0
Bridgeway Capital Management LLC	[2023-03-31]	SOLE	59,000.0	59,000.0
SilverArc Capital Management LLC	[2023-03-31]	SOLE	54,096.0	54,096.0
PNC Financial Services Group Inc	[2023-03-31]	DFND	53,612.0	53,612.0
Citadel Advisors LLC	[2023-03-31]	DFND	35,376.0	35,376.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	35,155.0	35,155.0
State Street Corp	[2023-03-31]	DFND	30,465.0	30,465.0
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