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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vivo Capital LLC	[2025-06-30]	SOLE	1,137,015	1,137,015
Octagon Capital Advisors LP	[2025-06-30]	SOLE	1,000,000	1,000,000
Nantahala Capital Management LLC	[2025-06-30]	SOLE	939,202	939,202
Great Point Partners LLC	[2025-06-30]	SOLE	0	796,558
Vanguard Group Inc	[2025-06-30]	SOLE	0	605,953
Logos Global Management LP	[2025-06-30]	SOLE	473,562	473,562
Acuta Capital Partners LLC	[2025-06-30]	SOLE	62,899	62,899
Geode Capital Management LLC	[2025-06-30]	DFND	58,786	58,786
JPMorgan Chase & Co	[2025-06-30]	DFND	21,709	21,709
State Street Corp	[2025-06-30]	DFND	12,523	12,523
Renaissance Technologies LLC	[2025-06-30]	SOLE	11,790	11,790
Lazard Asset Management LLC	[2025-06-30]	SOLE	11,575	11,575
Northern Trust Corp	[2025-06-30]	DFND	10,787	10,787
Morgan Stanley	[2025-06-30]	DFND	0	1,000
SBI Securities Co., Ltd.	[2025-06-30]	DFND	553	553
Harbour Investments Inc	[2025-06-30]	SOLE	0	100
Barclays PLC	[2025-06-30]	SOLE	80	80
Bank of America Corp /DE/	[2025-06-30]	DFND	0	64
Bogart Wealth LLC	[2025-06-30]	SOLE	6	6
Concourse Financial Group Securities Inc	[2025-06-30]	SOLE	0	0
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