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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2025-06-30]	DFND	12,238,517	12,238,803
BlackRock, Inc.	[2025-06-30]	SOLE	5,395,051	5,521,035
Deep Track Capital LP	[2025-06-30]	SOLE	5,380,449	5,380,449
Commodore Capital LP	[2025-06-30]	SOLE	4,875,000	4,875,000
Kynam Capital Management LP	[2025-06-30]	SOLE	4,427,927	4,427,927
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,371,797
VR Adviser LLC	[2025-06-30]	SOLE	3,882,709	3,882,709
Fairmount Funds Management LLC	[2025-06-30]	SOLE	3,424,821	3,459,913
Tang Capital Management LLC	[2025-06-30]	OTR	0	2,842,925
Paradigm Biocapital Advisors LP	[2025-06-30]	SOLE	2,741,576	2,741,576
State Street Corp	[2025-06-30]	DFND	2,385,544	2,553,426
Novo Holdings A/S	[2025-06-30]	SOLE	2,380,000	2,380,000
Maverick Capital Ltd	[2025-06-30]	SOLE	2,257,010	2,257,010
AllianceBernstein LP	[2025-06-30]	DFND	1,887,341	1,944,020
Eversept Partners LP	[2025-06-30]	SOLE	1,902,539	1,902,539
Baker Bros Advisors LP	[2025-06-30]	SOLE	1,744,406	1,744,406
Geode Capital Management LLC	[2025-06-30]	DFND	1,740,614	1,740,614
Loomis Sayles & Co L P	[2025-06-30]	DFND	1,314,916	1,338,472
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	1,298,825	1,298,825
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	1,130,520	1,265,754
Marshall Wace LLP	[2025-06-30]	OTR	0	1,207,871
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	1,108,586	1,108,586
Vivo Capital LLC	[2025-06-30]	SOLE	982,576	982,576
Goldman Sachs Group Inc	[2025-06-30]	DFND	899,695	899,825
Candriam S.C.A.	[2025-06-30]	SOLE	862,273	862,273
Woodline Partners LP	[2025-06-30]	SOLE	815,485	815,485
5AM Venture Management LLC	[2025-06-30]	SOLE	736,595	736,595
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	700,000	700,000
Citadel Advisors LLC	[2025-06-30]	DFND	676,243	676,243
Northern Trust Corp	[2025-06-30]	DFND	585,968	586,092
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