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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Casdin Capital LLC	[2024-06-30]	SOLE	3,136,411.0	3,526,411.0
Corvex Management LP	[2024-06-30]	SOLE	2,473,781.0	2,473,781.0
Oracle Investment Management Inc	[2024-06-30]	SOLE	1,105,768.0	1,105,768.0
Goldman Sachs Group Inc	[2024-06-30]	DFND	1,051,874.0	1,051,874.0
BlackRock Finance, Inc.	[2024-06-30]	SOLE	911,886.0	924,569.0
Blackstone Inc.	[2024-06-30]	OTR	0.0	835,062.0
Vanguard Group Inc	[2024-06-30]	SOLE	0.0	773,832.0
Gagnon Securities LLC	[2024-06-30]	SOLE	0.0	573,039.0
Driehaus Capital Management LLC	[2024-06-30]	SOLE	335,940.0	433,635.0
Deutsche Bank AG	[2024-06-30]	DFND	0.0	391,486.0
Assenagon Asset Management S.A.	[2024-06-30]	SOLE	366,296.0	366,296.0
Geode Capital Management LLC	[2024-06-30]	DFND	347,252.0	347,252.0
Millennium Management LLC	[2024-06-30]	SOLE	311,401.0	311,401.0
State Street Corp	[2024-06-30]	DFND	254,375.0	266,179.0
Gagnon Advisors LLC	[2024-06-30]	SOLE	0.0	255,059.0
Morgan Stanley	[2024-06-30]	DFND	233,266.0	237,541.0
Divisadero Street Capital Management LP	[2024-06-30]	SOLE	225,170.0	225,170.0
Jacobs Levy Equity Management Inc	[2024-06-30]	SOLE	202,063.0	202,063.0
Bosun Asset Management LLC	[2024-06-30]	SOLE	167,469.0	167,469.0
Point72 Asset Management LP	[2024-06-30]	DFND	0.0	156,745.0
Russell Investments Group, Ltd.	[2024-06-30]	DFND	104,520.0	133,529.0
Oberweis Asset Management Inc	[2024-06-30]	SOLE	122,000.0	122,000.0
Decheng Capital LLC	[2024-06-30]	SOLE	103,604.0	103,604.0
Tudor Investment Corp ET AL	[2024-06-30]	DFND	91,487.0	91,487.0
Renaissance Technologies LLC	[2024-06-30]	SOLE	90,373.0	90,373.0
Soleus Capital Management LP	[2024-06-30]	SOLE	87,000.0	87,000.0
Cubist Systematic Strategies, LLC	[2024-06-30]	DFND	0.0	76,701.0
Citadel Advisors LLC	[2024-06-30]	DFND	71,113.0	71,113.0
Susquehanna International Group LLP	[2024-06-30]	DFND	0.0	65,400.0
Northern Trust Corp	[2024-06-30]	DFND	11,066.0	63,622.0
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