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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
OrbiMed Advisors LLC	[2025-06-30]	SOLE	11,447,140	11,447,140
Tang Capital Management LLC	[2025-06-30]	OTR	0	8,223,612
RA Capital Management LP	[2025-06-30]	SOLE	7,541,000	7,541,000
Goldman Sachs Group Inc	[2025-06-30]	DFND	3,752,098	3,752,098
Vanguard Group Inc	[2025-06-30]	SOLE	0	3,259,681
Carlyle Group Inc.	[2025-06-30]	DFND	0	2,948,718
Acadian Asset Management LLC	[2025-06-30]	DFND	2,074,604	2,074,604
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	1,880,095	1,880,095
Renaissance Technologies LLC	[2025-06-30]	SOLE	1,153,816	1,153,816
Regeneron Pharmaceuticals Inc	[2025-06-30]	SOLE	968,183	968,183
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	901,600	901,600
Geode Capital Management LLC	[2025-06-30]	DFND	706,334	706,334
Alyeska Investment Group LP	[2025-06-30]	SOLE	655,665	655,665
RBF Capital, LLC	[2025-06-30]	SOLE	617,319	617,319
BlackRock, Inc.	[2025-06-30]	SOLE	599,487	599,487
Millennium Management LLC	[2025-06-30]	SOLE	592,327	592,327
Two Sigma Advisers LP	[2025-06-30]	SOLE	535,955	566,039
DAFNA Capital Management LLC	[2025-06-30]	SOLE	540,000	540,000
Two Sigma Investments LP	[2025-06-30]	SOLE	512,807	512,807
Citadel Advisors LLC	[2025-06-30]	DFND	487,606	487,606
Johnson & Johnson	[2025-06-30]	DFND	0	364,472
WealthEdge Investment Advisors LLC	[2025-06-30]	SOLE	0	313,108
Luminus Management LLC	[2025-06-30]	SOLE	289,935	289,935
State Street Corp	[2025-06-30]	DFND	246,921	246,921
FMR LLC	[2025-06-30]	DFND	244,002	244,778
Barclays PLC	[2025-06-30]	SOLE	150,000	150,000
Northern Trust Corp	[2025-06-30]	DFND	140,373	140,373
Vontobel Holding Ltd.	[2025-06-30]	DFND	80,000	80,000
Morgan Stanley	[2025-06-30]	DFND	72,226	72,226
Abacus Planning Group Inc	[2025-06-30]	SOLE	0	36,764
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