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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Nantahala Capital Management LLC	[2025-06-30]	SOLE	1,086,812	1,086,812
Stonepine Capital Management LLC	[2025-06-30]	SOLE	812,676	812,676
AWM Investment Company Inc	[2025-06-30]	SOLE	619,874	619,874
Kanen Wealth Management LLC	[2025-06-30]	SOLE	573,358	573,358
Renaissance Technologies LLC	[2025-06-30]	SOLE	89,913	89,913
Geode Capital Management LLC	[2025-06-30]	DFND	53,869	53,869
Two Sigma Investments LP	[2025-06-30]	SOLE	35,035	35,035
Vanguard Group Inc	[2025-06-30]	SOLE	0	27,888
BlackRock, Inc.	[2025-06-30]	SOLE	22,793	22,793
HRT Financial LP	[2025-06-30]	DFND	19,988	19,988
Jaffetilchin Investment Partners, LLC	[2025-06-30]	SOLE	17,437	17,437
Acadian Asset Management LLC	[2025-06-30]	DFND	10,237	10,237
MAI Capital Management	[2025-06-30]	SOLE	0	3,575
UBS Group AG	[2025-06-30]	DFND	2,787	3,047
Tower Research Capital LLC (TRC)	[2025-06-30]	DFND	2,538	2,538
Osaic Holdings Inc	[2025-06-30]	DFND	0	300
Morgan Stanley	[2025-06-30]	DFND	161	286
SBI Securities Co., Ltd.	[2025-06-30]	DFND	211	211
Wells Fargo & Company/MN	[2025-06-30]	DFND	0	127
CIBC Private Wealth Group LLC	[2025-06-30]	SOLE	83	83
Bank of America Corp /DE/	[2025-06-30]	DFND	0	63
Raymond James Financial Inc	[2025-06-30]	DFND	0	55
Group One Trading LLC	[2025-06-30]	SOLE	37	37
FNY Investment Advisers LLC	[2025-06-30]	SOLE	35,921	35
BNP Paribas Financial Markets	[2025-06-30]	DFND	0	23
Newedge Advisors LLC	[2025-06-30]	SOLE	0	21
Moser Wealth Advisors LLC	[2025-06-30]	SOLE	0	10
Vision Financial Markets LLC	[2025-06-30]	SOLE	2	2
Northwestern Mutual Wealth Management Co	[2025-06-30]	DFND	0	1
Jones Financial Companies LLLP	[2025-06-30]	SOLE	1	1
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