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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	6,424,238.0
Millennium Management LLC	[2023-03-31]	SOLE	5,460,380.0	5,460,380.0
HHLR Advisors Ltd	[2023-03-31]	OTR	0.0	4,974,041.0
BlackRock Inc.	[2023-03-31]	SOLE	4,765,496.0	4,793,679.0
NEA Management Company LLC	[2023-03-31]	DFND	3,467,406.0	3,467,406.0
Palo Alto Investors LP	[2023-03-31]	SOLE	3,465,152.0	3,465,152.0
Boxer Capital, LLC	[2023-03-31]	OTR	3,336,928.0	3,336,928.0
Artal Group S.A.	[2023-03-31]	DFND	3,028,171.0	3,028,171.0
Citadel Advisors LLC	[2023-03-31]	DFND	2,884,717.0	2,884,717.0
Platinum Investment Management Ltd	[2023-03-31]	SOLE	2,363,170.0	2,363,170.0
Acadian Asset Management LLC	[2023-03-31]	DFND	2,213,387.0	2,213,387.0
Susquehanna International Group LLP	[2023-03-31]	DFND	1,958,054.0	2,142,054.0
Octagon Capital Advisors LP	[2023-03-31]	SOLE	1,958,069.0	1,958,069.0
Two Sigma Investments LP	[2023-03-31]	SOLE	1,875,319.0	1,875,319.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	1,673,700.0	1,840,400.0
Marshall Wace LLP	[2023-03-31]	OTR	0.0	1,770,413.0
Ergoteles LLC	[2023-03-31]	SOLE	1,731,924.0	1,731,924.0
Walleye Capital LLC	[2023-03-31]	SOLE	1,612,721.0	1,612,721.0
HRT Financial LP	[2023-03-31]	DFND	1,548,153.0	1,548,153.0
Kynam Capital Management LP	[2023-03-31]	SOLE	1,502,866.0	1,502,866.0
CI Private Wealth LLC	[2023-03-31]	SOLE	1,360,386.0	1,360,386.0
Eversept Partners LP	[2023-03-31]	SOLE	1,352,065.0	1,352,065.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,346,259.0	1,346,259.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	1,331,822.0	1,331,822.0
State Street Corp	[2023-03-31]	DFND	1,260,787.0	1,323,497.0
Jane Street Group LLC	[2023-03-31]	DFND	1,291,144.0	1,291,144.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	1,100,274.0	1,100,274.0
Price T Rowe Associates Inc /MD/	[2023-03-31]	SOLE	176,025.0	1,064,039.0
Federated Hermes Inc	[2023-03-31]	DFND	940,405.0	940,405.0
Morgan Stanley	[2023-03-31]	DFND	762,493.0	769,810.0
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