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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Octagon Capital Advisors LP	[2025-06-30]	SOLE	18,350,000	18,350,000
NEA Management Company LLC	[2025-06-30]	DFND	18,093,034	18,093,034
BlackRock, Inc.	[2025-06-30]	SOLE	11,974,862	12,142,596
Vanguard Group Inc	[2025-06-30]	SOLE	0	11,157,178
Arch Venture Management LLC	[2025-06-30]	SOLE	0	8,055,916
FMR LLC	[2025-06-30]	DFND	7,296,507	7,315,325
683 Capital Management LLC	[2025-06-30]	DFND	6,640,100	6,640,100
Samsara Biocapital LLC	[2025-06-30]	SOLE	6,130,268	6,130,268
Palo Alto Investors LP	[2025-06-30]	SOLE	5,739,013	5,739,013
Siren, L.L.C.	[2025-06-30]	DFND	5,208,968	5,208,968
SilverArc Capital Management LLC	[2025-06-30]	SOLE	5,146,782	5,146,782
HHLR Advisors Ltd	[2025-06-30]	OTR	0	4,974,041
Geode Capital Management LLC	[2025-06-30]	DFND	4,555,080	4,555,080
Alyeska Investment Group LP	[2025-06-30]	SOLE	4,459,087	4,459,087
Corient Private Wealth LLC	[2025-06-30]	SOLE	3,666,283	3,693,683
Monaco Asset Management SAM	[2025-06-30]	SOLE	3,550,000	3,550,000
Opaleye Management Inc	[2025-06-30]	SOLE	3,545,000	3,545,000
Rock Springs Capital Management LP	[2025-06-30]	SOLE	3,266,960	3,266,960
Renaissance Technologies LLC	[2025-06-30]	SOLE	2,732,294	2,732,294
State Street Corp	[2025-06-30]	DFND	2,199,628	2,481,406
Deutsche Bank AG	[2025-06-30]	DFND	4,054	2,261,455
Two Sigma Investments LP	[2025-06-30]	SOLE	1,745,127	1,745,127
Eversept Partners LP	[2025-06-30]	SOLE	1,695,762	1,695,762
Two Sigma Advisers LP	[2025-06-30]	SOLE	1,614,500	1,672,200
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	1,621,419	1,621,419
Susquehanna International Group LLP	[2025-06-30]	OTR	382,677	1,608,377
Northern Trust Corp	[2025-06-30]	DFND	1,490,446	1,491,071
Platinum Investment Management Ltd	[2025-06-30]	SOLE	1,383,863	1,383,863
Laurion Capital Management LP	[2025-06-30]	SOLE	1,343,772	1,343,772
Focus Partners Wealth	[2025-06-30]	SOLE	0	1,150,000
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