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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Perceptive Advisors LLC	[2025-06-30]	SOLE	4,325,000	4,325,000
BIOS Capital Management LP	[2025-06-30]	OTR	0	3,683,429
Nantahala Capital Management LLC	[2025-06-30]	SOLE	3,345,923	3,345,923
Opaleye Management Inc	[2025-06-30]	SOLE	1,220,000	1,220,000
Mink Brook Asset Management LLC	[2025-06-30]	SOLE	1,197,616	1,197,616
Vanguard Group Inc	[2025-06-30]	SOLE	0	986,407
Bleichroeder LP	[2025-06-30]	SOLE	736,842	736,842
Voss Capital LP	[2025-06-30]	SOLE	541,159	541,159
Geode Capital Management LLC	[2025-06-30]	DFND	355,677	355,677
Renaissance Technologies LLC	[2025-06-30]	SOLE	153,309	153,309
Millennium Management LLC	[2025-06-30]	SOLE	127,844	127,844
Royal Bank of Canada	[2025-06-30]	DFND	127,250	127,250
Virtu Financial LLC	[2025-06-30]	DFND	79,346	79,346
State Street Corp	[2025-06-30]	DFND	70,473	70,473
Northern Trust Corp	[2025-06-30]	DFND	68,228	68,228
BlackRock, Inc.	[2025-06-30]	SOLE	46,094	46,094
Empowered Funds LLC	[2025-06-30]	OTR	42,065	42,065
Bridgeway Capital Management LLC	[2025-06-30]	SOLE	42,065	42,065
Two Sigma Investments LP	[2025-06-30]	SOLE	40,190	40,190
Captrust Financial Advisors	[2025-06-30]	SOLE	0	32,000
Morgan Stanley	[2025-06-30]	DFND	1	28,606
UBS Group AG	[2025-06-30]	DFND	28,110	28,110
Blair William & Co/IL	[2025-06-30]	SOLE	24,466	24,466
Citadel Advisors LLC	[2025-06-30]	DFND	19,000	19,000
Kestra Private Wealth Services LLC	[2025-06-30]	SOLE	0	19,000
Susquehanna International Group LLP	[2025-06-30]	OTR	17,303	17,303
Financial Gravity Companies, Inc.	[2025-06-30]	SOLE	16,555	16,555
James Investment Research Inc	[2025-06-30]	SOLE	16,364	16,364
Newedge Advisors LLC	[2025-06-30]	SOLE	16,364	16,364
XTX Topco Ltd	[2025-06-30]	DFND	15,808	15,808
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