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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
BlackRock Finance, Inc.	[2024-06-30]	SOLE	1,385,699.0	1,394,714.0
EcoR1 Capital LLC	[2024-06-30]	SOLE	1,271,342.0	1,271,342.0
Samsara Biocapital LLC	[2024-06-30]	SOLE	1,267,790.0	1,267,790.0
RTW Investments LP	[2024-06-30]	SOLE	1,070,565.0	1,070,565.0
Redmile Group LLC	[2024-06-30]	SOLE	1,013,663.0	1,013,663.0
Great Point Partners LLC	[2024-06-30]	DFND	0.0	1,004,291.0
Janus Henderson Group PLC	[2024-06-30]	DFND	0.0	834,791.0
Avidity Partners Management LP	[2024-06-30]	SOLE	727,537.0	727,537.0
Vanguard Group Inc	[2024-06-30]	SOLE	0.0	549,410.0
Casdin Capital LLC	[2024-06-30]	SOLE	524,616.0	524,616.0
Baker Bros Advisors LP	[2024-06-30]	SOLE	456,015.0	456,015.0
ArrowMark Colorado Holdings LLC	[2024-06-30]	SOLE	386,465.0	386,465.0
Morgan Stanley	[2024-06-30]	DFND	379,896.0	382,668.0
Deutsche Bank AG	[2024-06-30]	DFND	60,138.0	332,284.0
Geode Capital Management LLC	[2024-06-30]	DFND	222,062.0	222,062.0
State Street Corp	[2024-06-30]	DFND	199,590.0	209,853.0
Commodore Capital LP	[2024-06-30]	SOLE	200,000.0	200,000.0
Adage Capital Partners GP LLC	[2024-06-30]	SOLE	161,900.0	161,900.0
Nantahala Capital Management LLC	[2024-06-30]	SOLE	144,558.0	144,558.0
Invesco Ltd.	[2024-06-30]	DFND	0.0	133,694.0
Cormorant Asset Management LP	[2024-06-30]	DFND	107,344.0	107,344.0
Driehaus Capital Management LLC	[2024-06-30]	SOLE	102,187.0	102,187.0
Walleye Capital LLC	[2024-06-30]	SOLE	92,500.0	92,500.0
Stempoint Capital LP	[2024-06-30]	SOLE	78,601.0	78,601.0
FMR LLC	[2024-06-30]	DFND	72,286.0	72,286.0
Integral Health Asset Management LLC	[2024-06-30]	SOLE	70,000.0	70,000.0
Ghost Tree Capital LLC	[2024-06-30]	SOLE	70,000.0	70,000.0
Renaissance Technologies LLC	[2024-06-30]	SOLE	52,807.0	52,807.0
Marshall Wace LLP	[2024-06-30]	OTR	0.0	41,447.0
Susquehanna International Group LLP	[2024-06-30]	DFND	40,765.0	40,765.0
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