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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Samsara Biocapital LLC	[2025-06-30]	SOLE	1,717,127	1,717,127
RTW Investments LP	[2025-06-30]	SOLE	1,362,456	1,362,456
Casdin Capital LLC	[2025-06-30]	SOLE	1,295,361	1,295,361
Redmile Group LLC	[2025-06-30]	SOLE	1,276,676	1,276,676
EcoR1 Capital LLC	[2025-06-30]	SOLE	1,271,342	1,271,342
Baker Bros Advisors LP	[2025-06-30]	SOLE	991,691	991,691
BlackRock, Inc.	[2025-06-30]	SOLE	957,886	977,682
Toronto Dominion Bank	[2025-06-30]	DFND	0	681,337
Vanguard Group Inc	[2025-06-30]	SOLE	0	603,115
ArrowMark Colorado Holdings LLC	[2025-06-30]	SOLE	585,397	585,397
Morgan Stanley	[2025-06-30]	DFND	543,106	545,603
Great Point Partners LLC	[2025-06-30]	SOLE	0	485,859
FMR LLC	[2025-06-30]	DFND	468,042	468,476
Commodore Capital LP	[2025-06-30]	SOLE	427,866	427,866
Millennium Management LLC	[2025-06-30]	SOLE	307,805	307,805
Octagon Capital Advisors LP	[2025-06-30]	SOLE	303,000	303,000
Geode Capital Management LLC	[2025-06-30]	DFND	247,775	247,775
UBS Group AG	[2025-06-30]	DFND	236,002	240,319
State Street Corp	[2025-06-30]	DFND	196,348	210,848
Jennison Associates LLC	[2025-06-30]	DFND	167,563	167,563
Deutsche Bank AG	[2025-06-30]	DFND	62,363	151,119
Susquehanna International Group LLP	[2025-06-30]	OTR	26,006	150,106
Blair William & Co/IL	[2025-06-30]	SOLE	87,916	133,236
Rock Springs Capital Management LP	[2025-06-30]	SOLE	104,339	104,339
Bank of America Corp /DE/	[2025-06-30]	DFND	1,900	95,401
Northern Trust Corp	[2025-06-30]	DFND	91,572	91,572
Woodline Partners LP	[2025-06-30]	SOLE	83,835	83,835
DAFNA Capital Management LLC	[2025-06-30]	SOLE	51,096	51,096
Wellington Management Group LLP	[2025-06-30]	DFND	0	44,904
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AM	[2025-06-30]	DFND	34,761	34,761
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