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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Nantahala Capital Management LLC	[2025-06-30]	SOLE	2,318,017	2,318,017
Rosalind Advisors, Inc.	[2025-06-30]	SOLE	2,289,099	2,289,099
OrbiMed Advisors LLC	[2025-06-30]	SOLE	2,133,405	2,133,405
Soleus Capital Management LP	[2025-06-30]	SOLE	1,886,207	1,886,207
Marshall Wace LLP	[2025-06-30]	OTR	0	1,860,405
Parkman Healthcare Partners LLC	[2025-06-30]	SOLE	1,235,305	1,235,305
Velan Capital Investment Management LP	[2025-06-30]	SOLE	904,029	904,029
Pura Vida Investments LLC	[2025-06-30]	SOLE	450,517	450,517
Affiance Financial LLC	[2025-06-30]	SOLE	0	189,122
UBS Group AG	[2025-06-30]	DFND	124,638	124,638
Huntleigh Advisors Inc	[2025-06-30]	SOLE	124,228	124,228
Morgan Stanley	[2025-06-30]	DFND	1	94,141
Ironwood Investment Management LLC	[2025-06-30]	SOLE	60,547	60,547
Northern Trust Corp	[2025-06-30]	DFND	45,320	45,320
Raymond James Financial Inc	[2025-06-30]	DFND	0	44,604
Schonfeld Strategic Advisors LLC	[2025-06-30]	SOLE	37,489	37,489
BlackRock, Inc.	[2025-06-30]	SOLE	36,573	36,573
Mesirow Financial Investment Management Inc	[2025-06-30]	SOLE	30,000	30,000
Courier Capital LLC	[2025-06-30]	SOLE	0	30,000
Citadel Advisors LLC	[2025-06-30]	DFND	26,176	26,176
Hollencrest Capital Management	[2025-06-30]	SOLE	20,000	20,000
Creative Planning	[2025-06-30]	SOLE	0	19,555
Geode Capital Management LLC	[2025-06-30]	DFND	18,244	18,244
Vestia Personal Wealth Advisors	[2025-06-30]	SOLE	18,000	18,000
Millennium Management LLC	[2025-06-30]	SOLE	17,018	17,018
Avestar Capital LLC	[2025-06-30]	SOLE	15,000	15,000
McKinley Carter Wealth Services Inc	[2025-06-30]	SOLE	0	10,000
Brown Advisory Inc	[2025-06-30]	DFND	10,000	10,000
AdvisorNet Financial Inc	[2025-06-30]	SOLE	8,783	8,783
JPMorgan Chase & Co	[2025-06-30]	DFND	2,853	2,853
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